Liposarcoma differential diagnosis
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Differential diagnosis includes nonadipocytic lesions such as inflammatory myofibroblastic tumor and Castleman’s disease.[1]
Few are tabulated below.
| Disease | Description |
|---|---|
| Spindle cell lipoma | Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles |
| Neurofibroma | Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei |
| Dermatofibrosarcoma protuberans | Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern |
| Malignant peripheral nerve sheath tumor | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases |
References
- ↑ 1.0 1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.