Liposarcoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Natural History

• The natural history of liposarcoma would depend on the histopathological subtype and location.
• Liposarcomas may remain asymptomatic for a long time, specially if they are located in the retroperitoneum.
• The common presentation for a liposarcoma located in the soft tissue of the skin is a painless growing mass without other symptoms.
• The lower extremities are the most common location of liposarcomas.
• Between 10 and 15% of patients may present with pain in the affected region.
• Retroperitoneal liposarcomas may present as a dull abdominal pain, weight loss and increase abdominal girth.

Prognosis

The prognosis of liposarcoma will depend on the histopathological subtype. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The pleomorphic liposarcoma has a high metastasis potential and a high recurrence.