Familial adenomatous polyposis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The incidence of familial adenomatous polyposis was estimated to be 1 case per 10,000 individuals in the US.

Epidemiology and Demographics

Incidence

• The incidence of the mutation is between 1 in 10,000 and 1 in 15,000 births.

Age

• By age 35 years, 95% of individuals with FAP have polyps. Without colectomy, colon cancer is virtually inevitable.

• The mean age of colon cancer in untreated individuals is 39 years (range 34-43 years).