Mast cell leukemia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
If left untreated, patients with mast cell leukemia may progress to develop weight loss, ascites, and bone abnormalities.[1] Common complications of mast cell leukemia include hepatosplenomegaly, lymphadenopathy, and osteoporosis.[1] Prognosis is generally poor, and the median survival time is less than six months.[2]
Natural history
If left untreated, patients with mast cell leukemia may progress to develop hepato-splenomegaly, lymph nodes enlargement, bone abnormalities, ascites, and weight loss.[1] Mast cell leukemia is by far an incurable disease with an aggressive behavior.[1]
Complications
Common complications of mast cell leukemia include:[1]
- Hepatosplenomegaly
- Lymphadenopathy
- Osteoporosis
Prognosis
Prognosis is generally poor, and the median survival time is less than six months.[2]
Prognostic factors
- Advanced age
- History of weight loss
- Anemia
- Thrombocytopenia
- Hypoalbuminemia
- Excess of bone marrow blasts
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 2.0 2.1 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.