Esthesioneuroblastoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Natural History
Complications
Prognosis
Most studies have found a correlation between Hyams grade and prognosis [13,17,21,23]. In a meta-analysis that included five studies in which lesions were graded histologically, the mean five-year survival was 56 percent for those with low-grade lesions (Hyams I and II) versus 20 percent for those with high-grade lesions (Hyams III and IV) [23]. However, a SEER study of 281 patients treated from 1973 to 2010 showed that patients with grade I and II tumors had a 10-year overall survival rate of 67 percent and those with high grade tumors (III and IV) had a 10-year overall survival rate of 34 percent. For high-grade tumors, multivariate analysis showed Kadish stage predicted for worse disease-specific survival and radiation independently predicted for improved disease-specific survival (B-Tajudden).