Hemophilia A epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The incidence of Hemophilia A is approximately 1 per 5,000 to 10,000 males worldwide. In 2016, it was estimated that 20,000 males in the United States were living with Hemophilia A

Epidemiology and Demographics

Age

Patients of all age groups may present with Hemophilia A. Patients with more severe disease (i.e. greater deficiency in Factor VIII) present earlier than those with only mild disease. Acquired hemophilia usually presents in middle-aged or elderly individuals, as well as in females in the peri-partum period.

Gender

Males are more commonly affected with Hemophilia A than females. In rare cases, females heterozygous for the condition may present with features of the disease, due to random X-inactivation or lyonization.

Race

There is no racial predilection for Hemophilia A