Acute retinal necrosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Laboratory Findings
Laboratory findings associated with Acute retinal necrosis are those used to determine the viral pathogen, obtained from aqueous humor or the vitreous.[1]
- Qualitative and Real-time Polymerase chain reaction[1]
- PCR-tests for Acute retinal necrosis patients will produce genomic evidence of the causative virus.
- It is the preferred test due to the 90% specificity in detecting Herpes simplex virus (HSV), Varicella-zoster virus (VZV), and Cytomegalovirus (CMV).
- Viral cultures may reveal positive results for HSV-1, HSV-2, VZV, or CMV.[2]
- Immunoflourescence may reveal antibodies indicative of Acute retinal necrosis pathogens.[3]
- Detection of indicative antibodies via Goldmann-witmer coefficient.[4]
References
- ↑ 1.0 1.1 Brydak-Godowska J, Borkowski P, Szczepanik S, Moneta-Wielgoś J, Kęcik D (2014). "Clinical manifestation of self-limiting acute retinal necrosis". Med. Sci. Monit. 20: 2088–96. doi:10.12659/MSM.890469. PMC 4226315. PMID 25356955.
- ↑ Silva RA, Berrocal AM, Moshfeghi DM, Blumenkranz MS, Sanislo S, Davis JL (2013). "Herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review". Graefes Arch. Clin. Exp. Ophthalmol. 251 (2): 559–66. doi:10.1007/s00417-012-2164-8. PMID 23052715.
- ↑ Singh A, Preiksaitis J, Ferenczy A, Romanowski B (2005). "The laboratory diagnosis of herpes simplex virus infections". Can J Infect Dis Med Microbiol. 16 (2): 92–8. PMC 2095011. PMID 18159535.
- ↑ De Groot-Mijnes JD, Rothova A, Van Loon AM, Schuller M, Ten Dam-Van Loon NH, De Boer JH, Schuurman R, Weersink AJ (2006). "Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis". Am. J. Ophthalmol. 141 (2): 313–8. doi:10.1016/j.ajo.2005.09.017. PMID 16458686.