Graves' disease laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Overview
The laboratory findings for Graves' disease are elevated levels of serum thyroxine (T4) and triiodothyronine (T3) and undetectable serum TSH.
Laboratory Findings
The laboratory findings for Graves' disease are:
- Elevated levels of serum thyroxine (T4) and triiodothyronine (T3)
- Undetectable serum TSH.
Total T4 and T3 measurements are influenced by multiple conditions affecting serum thyroxine-binding globulin (TBG) thus, free thyroid hormone (free T4 (FT4) and free T3 (fT3)) are the gold standard measurements to diagnose Graves' disease.[1]
Antibodies against the TSH receptor (TRAbs) are pathognomonic for Graves' disease. They are detectable in the serum of about 98% of untreated patients.[2]
Detection of TRAbs rules out other causes of thyrotoxicosis.[3]
Nnti-thyroid peroxidase (TPO) and antithyroglobulin (Tg) antibodies are also detectable in many patients with Graves' disease but it's not recommended to measure them in all patients for diagnosis.
References
- ↑ Dufour DR (2007). "Laboratory tests of thyroid function: uses and limitations". Endocrinol. Metab. Clin. North Am. 36 (3): 579–94, v. doi:10.1016/j.ecl.2007.04.003. PMID 17673120.
- ↑ Zöphel K, Roggenbuck D, Schott M (2010). "Clinical review about TRAb assay's history". Autoimmun Rev. 9 (10): 695–700. doi:10.1016/j.autrev.2010.05.021. PMID 20594972.
- ↑ Barbesino G, Tomer Y (2013). "Clinical review: Clinical utility of TSH receptor antibodies". J. Clin. Endocrinol. Metab. 98 (6): 2247–55. doi:10.1210/jc.2012-4309. PMC 3667257. PMID 23539719.