Cerebral palsy laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal among patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- There are no diagnostic laboratory findings associated with cerebral palsy
- The American Academy of Neurology (AAN) recommends lab studies
- If there is no specific structural abnormality present-
- Presence of atypical features in history or physical examination
- Cerebral palsy associated with brain malformation
- Following labs may help to rule out other diseases
- Thyroid function tests- to rule out muscle or movement disorders
- Lactate and pyruvate levels- may show mitochondrial abnormalities
- Organic and amino acids- serum and urine levels may be deranged in inherited metabolic disorders
- Ammonia levels- elevated in liver dysfunction or urea cycle defect
- Chromosomal analysis:[1]
- Karyotype analysis
- Specific DNA testing
- Lumbar puncture:[2]
- Elevated CSF protein levels
- Low cerebrospinal fluid (CSF) glucose concentration (hypoglycorrhachia
- Diagnostic testing for coagulation disorders, if cerebral infarction is suspected
References
- ↑ Ashwal S, Russman BS, Blasco PA, Miller G, Sandler A, Shevell M, Stevenson R (2004). "Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society". Neurology. 62 (6): 851–63. PMID 15037681.
- ↑ Pons R, Collins A, Rotstein M, Engelstad K, De Vivo DC (2010). "The spectrum of movement disorders in Glut-1 deficiency". Mov. Disord. 25 (3): 275–81. doi:10.1002/mds.22808. PMID 20063428.
- ↑ Senbil N, Yüksel D, Yilmaz D, Gürer YK (2007). "Prothrombotic risk factors in children with hemiplegic cerebral palsy". Pediatr Int. 49 (5): 600–2. doi:10.1111/j.1442-200X.2007.02424.x. PMID 17875083.
- ↑ Simchen MJ, Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G (2009). "Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke". Stroke. 40 (1): 65–70. doi:10.1161/STROKEAHA.108.527283. PMID 18927445.