The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3gene.[1] The protein encoded by this gene is a subunit of the glycine receptor.[1]
Variants of this receptor subunit is associated with susceptibility to epilepsy.[2]
References
↑ 1.01.1Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID9677400.
↑Sobetzko D, Sander T, Becker CM (August 2001). "Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies". Am. J. Med. Genet. 105 (6): 534–8. doi:10.1002/ajmg.1488. PMID11496371.
Further reading
Breitinger HG, Villmann C, Rennert J, et al. (2002). "Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels". J. Neurochem. 83 (1): 30–6. doi:10.1046/j.1471-4159.2002.01109.x. PMID12358726.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID19086053.
