Wilson's disease history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. Common hepatic symptoms include abdominal distension, abdominal pain, fatigue, bleeding tendency, and esophageal varices. Common neuropsychiatric symptoms include tremors, ataxia, dysarthria, and impulsiveness. Less common symptoms of wilson's disease include urolithiasis and hematuria.
History
- Family history of Wilson's disease in any other family member is important in the diagnosis as Wilson's disease is usually inhereted.
Common symptoms
- Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. [1]
- Advanced cases of Wilson's disease can be presented as hepatic failure or chronic liver disease which may be associated with cirrhosis. Neuorological and psychiatric manifestations are also present in most cases.
- Common symptoms of Wilson's disease include the following: [2][3]
- Hepatic symptoms:
- Abdominal distension
- Abdominal pain
- Fatigue
- Bleeding tendency
- Confusion
- Esophageal varices
- Spider naevi (When associated with cirrhosis)
- Neuropsychiatric symptoms:
- Tremors
- Ataxia
- Dysarthria
- Dystonia
- Excessive salivation
- Impulsiveness
- Schizophrenic disorders
- Anxiety
- Depression
- Hepatic symptoms:
Less common symptoms
- Less common symptoms of Wilson's disease include the following:
- Renal symptoms:
- Urolithiasis
- Hematuria
- Renal symptoms:
References
- ↑ Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML (2007). "Wilson's disease". Lancet. 369 (9559): 397–408. doi:10.1016/S0140-6736(07)60196-2. PMID 17276780.
- ↑ Merle U, Schaefer M, Ferenci P, Stremmel W (2007). "Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study". Gut. 56 (1): 115–20. doi:10.1136/gut.2005.087262. PMID 16709660.
- ↑ European Association for Study of Liver (2012). "EASL Clinical Practice Guidelines: Wilson's disease". J Hepatol. 56 (3): 671–85. doi:10.1016/j.jhep.2011.11.007. PMID 22340672.