VIPoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.[1] Common complications of VIPoma include metastasis, cardiac arrest from low blood potassium level, and dehydration. The presence of metastasis is associated with a particularly poor prognosis among patients with VIPoma, with a 5 year survival rate of 20% and 3 year survival rate of 40%.[2]
Natural History
- If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.[1]
- VIPoma have a very slow growth rate compared to most malignant tumors.
Complications
Common complications of VIPoma include:
- Metastasis
- Cardiac arrest from low blood potassium level
- Dehydration
Prognosis
- Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.
- The 5-year survival for patients with localized VIPoma is 94% whereas metastatic pancreatic VIPomas is 60%, respectively.[3]
References
- ↑ 1.0 1.1 Natanzi, Naveed; Amini, Mazyar; Yamini, David; Nielsen, Shawn; Ram, Ramin (2009). "Vasoactive Intestinal Peptide Tumor". Scholarly Research Exchange. 2009: 1–7. doi:10.3814/2009/938325. ISSN 1687-8299.
- ↑ Smith, Stephen L.; Branton, Susan A.; Avino, Anthony J.; Martin, J.Kirk; Klingler, Paul J.; Thompson, Geoffrey B.; Grant, Clive S.; van Heerden, Jon A. (1998). "Vasoactive intestinal polypeptide secreting islet cell tumors: A 15-year experience and review of the literature". Surgery. 124 (6): 1050–1055. doi:10.1067/msy.1998.92005. ISSN 0039-6060.
- ↑ Nilubol N, Freedman EM, Quezado MM, Patel D, Kebebew E (2016). "Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report". J Clin Endocrinol Metab. 101 (10): 3564–3567. doi:10.1210/jc.2016-2051. PMC 5052354. PMID 27583474.