Familial adenomatous polyposis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]

Overview

The mainstay of treatment for familial adenomatous polyposis is surgery. However, non-steroidal anti-inflammatory drugs (NSAIDs) such as sulindac and celecoxib are recommended to decrease the size and number of colon polyps.

The mainstay of treatment for familial adenomatous polyposis is surgery.
Pharmacologic medical therapies for familial adenomatous polyposis include non-steroidal anti-inflammatory drugs (NSAIDs).^[1]^[2]
- Preferred regimen (1): Sulindac
- Preferred regimen (2): Celecoxib 400 mg twice daily for 6 months

Note (1): non-steroidal anti-inflammatory drugs (NSAIDs) decrease the size and number of colon polyps.

↑ King JE, Dozois RR, Lindor NM, Ahlquist DA (2000). "Care of patients and their families with familial adenomatous polyposis". Mayo Clin. Proc. 75 (1): 57–67. doi:10.4065/75.1.57. PMID 10630758.
↑ Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). "Familial adenomatous polyposis". Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.