Cryptogenic organizing pneumonia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Laboratory Findings

• There are no specific laboratory findings associated with cryptogenic organizing pneumonia.
• If there is the history of cryptogenic organizing pneumonia and patients present with a cough, fever, and dyspnea then following laboratory test is to be done:
  • Complete blood count with differentials- leukocytosis is found in most of the patients.
  • Blood urea nitrogen
  • Creatinine
  • Urinalysis
  • ESR
  • C-reactive protein
• To find the etiology of cryptogenic organizing pneumonia following tests are done:
  • Test for antibodies to rule out connective tissue disorder.
    • Antinuclear antibody
    • Rheumatoid factor
    • Anti-topoisomerase [anti-Scl70]
    • Anti-centromere antibody
    • Anti-double-stranded DNA
    • Anti-JO1
  • To rule out pneumonia, following tests are done:
    • Blood cultures
    • Sputum gram stain
    • Sputum enzyme immunoassay (EIA)
    • Immunofluorescence
    • Polymerase chain reaction (PCR) for respiratory viruses
    • Urinary studies for pneumococcal and Legionella antigen
    • HIV testing