Goodpasture syndrome physical examination

Goodpasture syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

A complete medical history and comprehensive renal and pulmonary exam must be preformed to help identify and properly diagnose Goodpasture syndrome.

Physical Examination

A complete medical history and comprehensive renal and pulmonary exam must be preformed to help identify and properly diagnose Goodpasture syndrome. A thorough physical examination can provide insight into possible causes and associated underlying conditions. The following findings may be present during a physical examination of Goodpasture syndrome:

• Hypertension
• Tachypnea
• Inspiratory crackles present in the base of the lungs
• Cyanosis
• Hepatosplenomegaly
• Rash
• Edema

Physical Examination

• The presence of tachypnea, inspiratory crackles, edema and hypertension on physical examination are suggestive of Goodpasture syndrome.

Appearance of the Patient

• Patients with Goodpasture syndrome usually appear fatigued.

Vital Signs

• Low-grade fever
• Tachycardia
• Tachypnea
• High blood pressure

Skin

• Skin examination of patients with severe Goodpasture syndrome may present with cyanosis from auto-antibodies induced lung tissue injury.

HEENT

• HEENT examination of patients with Goodpasture syndrome is usually normal.

Lungs

• Lungs are hyporresonant
• Fine Crackles upon auscultation of the lung bases may be present unilaterally/bilaterally

Abdomen

• Abdominal tenderness may be present over renal angles.
• Hepatosplenomegaly (present in few cases)

Genitourinary

• Hematuria may be observed.

Extremities

• Extremities examination of patients with Goodpasture syndrome may present with:
• Cyanosis
• Pitting edema of the lower extremities