Goodpasture syndrome other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

Other diagnostic studies for Goodpasture syndrome include renal biopsy. In patients with inconclusive lab and imaging findings, renal biopsy remains the gold standard in establishing the presence of Goodpasture syndrome. A renal biopsy can also identify the severity of disease and guide medical therapy.

Other Diagnostic Studies

• Other diagnostic studies for Goodpasture syndrome include renal biopsy.
• In patients with inconclusive lab and imaging findings, renal biopsy remains the gold standard in establishing the presence of Goodpasture syndrome. However, it may be observed renal biopsy is preferred over pulmonary biopsy because of abundance of autofluorecene.
• Renal biopsy helps establish the histopathological evidence of anti-glomerular basement membrane antibodies.
• Renal biospy can help identify the early focal proliferative changes in glomeruli which leads to inflammation, necrosis and crescent formation
• Under direct immunofluorescence, linear immunoglobulin G (IgG) deposits are seen around the glomerular basement membrane.