Goodpasture syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3] Akshun Kalia M.B.B.S.[4]

Overview

Laboratory findings consistent with the diagnosis of Goodpasture syndrome include presence of auto-antibodies such as anti-glomerular basement membrane antibodies.Other findings associated with pulmonary and renal injury include elevated blood urea nitrogen, low-grade proteinuria, gross or microscopic hematuria, and red cell casts.

Laboratory Findings

• Laboratory findings consistent with the diagnosis of Goodpasture syndrome include presence of auto-antibodies such as anti-glomerular basement membrane antibodies.
• Other findings associated with pulmonary and renal injury include elevated blood urea nitrogen, low-grade proteinuria, gross or microscopic hematuria, and red cell casts.
• If laboratory test cannot detect the presence of anti-glomerular basement membrane antibodies, other tests such as anti-neutrophil cytoplasmic antibodies should be done to determine and rule out the presence of ANCA associated vasculitis.
• Routine laboratory test that may be ordered to help in identifying the cause are:
  • Complete blood count (leukocytosis and anemia)
  • Renal function test (BUN, S. creatinine )
  • Urinalysis for proteinuria, hematuria, and red cell casts
  • ESR and CRP