Hemophilia A epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2]
Overview
The incidence of Hemophilia A is approximately 1 per 5,000 to 10,000 males worldwide. In 2016, it was estimated that 20,000 males in the United States were living with Hemophilia A.[1]
In contrast, Hemophilia B is a much rarer disease affecting 1 in 30,000 males worldwide.
Epidemiology and Demographics
- Age
- Patients of all age groups may present with hemophilia A and B. Patients with more severe disease (i.e. greater deficiency in Factor VIII/IX) present earlier(usually neonatal or infantile period) than those with only mild disease. Acquired hemophilia usually presents in middle-aged or elderly individuals, as well as in females in the peri-partum period.
- Gender
- As Hemophilia inheritance is linked to chromosome X and the gene is recessive, the disease mainly appears in males as they have only one X chromosome and the penetrance is 100%. In rare cases, females heterozygous for the condition may present with features of the disease, due to random X-inactivation or lyonization or patients with Turner syndrome.
- Race
- There is no racial predilection for Hemophilia A and B.[2]
References
- ↑ What is Hemophilia? – NHLBI, NIH. Available at http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia. Accessed on Sept 20, 2016
- ↑ Data & Statistics | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/data.html Accessed on July 30,2016