Renal amyloidosis physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].
OR
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
The presence of [finding(s)] on physical examination is diagnostic of [disease name].
OR
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].
Physical Examination
Physical examination of patients with renal amyloidosis is usually remarkable for swelling, chronic renal failure, hepatosplenomegaly[1], facial or neck purpura and macroglossia[2]. Fatigue and unintentional weight loss, are common in patients with AL amyloidosis. [3][4]
Appearance of the Patient
- Patient appears well in the earlier stages of the disease
- Patient appears ill in the late stages of the disease due to multi-organ involvement
Vital Signs
- Fever depends on accompanying infection
- Tachycardia/bradycardia depends on the accompanying complication
- Tachypnea/bradypnea depends on the accompanying complication
Skin
Eyes
Lungs
- Pulmonary fine crackles
- Faint pulmonary auscultation, suggestive of pleural effusion
- Decreased tactile fremitus
- Dull percussion
Abdomen
- Abdominal distension
- Shifting dullness, suggestive of ascites
- Dull percussion
Extremities
- Pitting edema in lower extremities bilaterally
References
- ↑ Kyle RA, Gertz MA (January 1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases". Semin. Hematol. 32 (1): 45–59. PMID 7878478.
- ↑ Eder L, Bitterman H (June 2007). "Image in clinical medicine. Amyloid purpura". N. Engl. J. Med. 356 (23): 2406. doi:10.1056/NEJMicm061510. PMID 17554122.
- ↑ Baker KR, Rice L (2012). "The amyloidoses: clinical features, diagnosis and treatment". Methodist Debakey Cardiovasc J. 8 (3): 3–7. PMC 3487569. PMID 23227278.
- ↑ Menke DM, Kyle RA, Fleming CR, Wolfe JT, Kurtin PJ, Oldenburg WA (August 1993). "Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis". Mayo Clin. Proc. 68 (8): 763–7. PMID 8331978.
- ↑ Eder L, Bitterman H (June 2007). "Image in clinical medicine. Amyloid purpura". N. Engl. J. Med. 356 (23): 2406. doi:10.1056/NEJMicm061510. PMID 17554122.