Aplastic anemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]

Overview

Aplastic anemia can be classified into mild, moderate, severe, and very severe depending on the severity of cellularity of bone marrow and the blood tests.

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:

• • Moderately severe aplastic anemia or non severe AA (nSAA)
  • Severe aplastic anemia (SAA)
  • Very severe aplastic anemia(vSAA)

Classification of aplastic anemia (two out of three criteria must be met)

	nSAA	SAA	vSAA
Reticulocytes	<20G/L	<20G/L	<20G/L
Platelets	<50 G / L	<20G/L	<20G/L
Neutrophilic granulocytes	<1.0 G / L	<0.5G/L	0.2G/l

This classification is of prognostic relevance and has an influence on therapeutic procedures.

classification based on the presumed etiology

Acquired
Idiopathic
Secondry	Irradiation Drugs Idiosyncratic reactions Viruses Immune diseases Pregnancy PNH
Inherited	Fanconis anemia Dyskeratosis congenital Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome