Aplastic anemia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]
Overview
The cause of the damage can be acquired or inherited. Acquired aplastic anemia is more common, and sometimes it's only temporary. Inherited aplastic anemia is rare. More than half of the cases of aplastic anemia are idiopathic. Chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated as the causative factor in the other cases. Some research suggests that stem cell damage may occur because the body's immune system attacks its own cells by mistake.
Causes
Acquired Causes
Many diseases, conditions, and factors can cause aplastic anemia, including:
- Toxins, such as pesticides, arsenic, and benzene.
- Radiation and chemotherapy
- Medicines, such as Albendazole, Cefadroxil, Chlorpromazine, chloramphenicol (an antibiotic rarely used in the United States, Carbamazepine, Hydroxychloroquine, Methimazole, Orphenadrine, Oxcarbazepine, Phenytoin, Quinine, Phenylbutazone, Sulindac, Sulfadiazine, Sulfasalazine, Valganciclovir hydrochloride.
- Infectious diseases, such as hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV.
- Collagen vascular disease
- Thymoma
- Autoimmune disorders, such as lupus and rheumatoid arthritis.
- Pregnancy (aplastic anemia that occurs during pregnancy often goes away after delivery.)
- Metastaic involvement of bone marrow
Inherited Causes
Certain inherited conditions can damage the stem cells and lead to aplastic anemia. Examples include:
Drugs Associated
- Ceftazidime
- Cefaclor
- Cefaclor
- Certolizumab pegol
- Chlorpropamide
- Chloramphenicol sodium succinate
- Dactinomycin
- Dapsone
- Eltrombopag
- Felbamate
- Flurbiprofen
- Flucytosine
- interferon alfacon-1
- Isoniazid
- Lincomycin Hydrochloride
- Meprobamate
- Nilutamide
- Oxaprozin
- Penicillamine
- Probenecid
- Tolbutamide
- Tolazamide
- Sodium aurothiomalate
- Sodium phenylbutyrate
- Sulfamethoxazole/Trimethoprim (oral)
- Sulfasalazine
- Sulfacetamide
Other Causes
- Exposure to toxins
- Radiation or chemotherapy
- Have certain infectious diseases, autoimmune disorders, or inherited conditions
Life-threatening Causes[edit | edit source]
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes[edit | edit source]
Common causes of [disease name] may include:
- [Cause1]
- [Cause2]
- [Cause3]
OR
- [Disease name] is caused by an infection with [pathogen name].
- [Pathogen name] is caused by [pathogen name].
Less Common Causes[edit | edit source]
Less common causes of [disease name] include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes[edit | edit source]
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System[edit | edit source]
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order[edit | edit source]
List the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
- Cause 3
- Cause 4