Liposarcoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Medical therapy for liposarcoma includes Chemotherapy, chemoradiation, immunotherapy, and targeted therapy.
Medical Therapy
Chemotherapy
- Chemotherapy may be used with radiation therapy either before or after surgery to shrink the tumor or kill any remaining cancer cells.
- If the cancer has spread to other areas of the body, chemotherapy may be used to shrink tumors and reduce the associated pain and discomfort.
- Patients with soft tissue sarcomas usually receive chemotherapy intravenously.
Chemoradiation
- Sometimes the targeted therapy is given along with radiation.
- They may be given together or at different intervals.
Targeted Therapy
- It stops the growth of the molecules involved in growth of cancer cells.
- It blocks the growth signals.
- Most targeted therapy comes in pill form and some needs to be injected.
Immunotherapy
- Immunotherapy increases the activity of the immune system and improves body's ability to find and destroy cancer cells.
- Few of the drugs used for immune therapy are listed below.[1]
| Drug | Type of drug |
|---|---|
| Bevacizumab | Targeted therapy |
| Celecoxib | Targeted therapy |
| Crizotinib | Targeted therapy |
| Dacarbazine | Chemotherapy |
| Dasatinib | Targeted therapy |
| Docetaxel | Chemotherapy |
| Doxorubicin | Chemotherapy |
| Epirubicin hydrochloride | Chemotherapy |
| Everolimus | Chemotherapy |
| Gemcitabine hydrochloride | Chemotherapy |
| Ifosfamide | Chemotherapy |
| Imatinib mesylate | Targeted therapy |
| Interferon alpha 2B | Immunotherapy |
| Mesna | Chemotherapy |
| Methotrexate | Chemotherapy |
| Nilotinib | Chemotherapy |
| Paclitaxel | Chemotherapy |
| Pazopanib | Targeted therapy |
| Regorafenib | Targeted therapy |
| Sorafenib tosylate | Targeted therapy |
| Sirolimus | Chemotherapy |
| Sulindac | Chemotherapy |
| Sunitinib malate | Targeted therapy |
| Tamoxifen citrate | Targeted therapy |
| Temozolomide | Chemotherapy |
| Toremifene citrate | Targeted therapy |
| Vinblastine citrate | Chemotherapy |
| Vinblastine tartrate | Chemotherapy |
Regimen
| Drugs | Dose |
|---|---|
| Doxorubicin | Doxorubicin 75 mg/m2; 28 day cycle |
| Pegylated liposomal doxorubicin | 40 - 50 mg/m2 ; 28 day cycle |
| AI regimen | Doxorubicin 25 mg/m2, Ifosfamide 3 g/m2 21 day cycle |
| MAID regimen | Doxorubicin 20 mg/m2, Ifosfamide 2.5 g/m2, Dacarbazine 300mg/m2 21 day cycle |
| AD regimen | Doxorubicin 20 mg/m2, Dacarbazine 300 mg/m2; 21 day cycle |
| Metronomic cyclophosphamide | Oral daily cyclophosphamide 50mg/day for 21 days on 28 day cycle |
| Docetaxel-Gemcitabine | Gemcitabine 900 mg/m2 , Docetaxel 100 mg/m2 for 21 day cycle |
| Trabectedin | Trabectedin 1.5 mg/m2 21 day cycle[2] |