Haff disease medical therapy
|
Haff disease Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Haff disease medical therapy On the Web |
|
American Roentgen Ray Society Images of Haff disease medical therapy |
|
Risk calculators and risk factors for Haff disease medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
Medical therapy
Management of Rhabdomyolysis
The goal of rhabdomyolysis is adequate fluid hydration with normal isotonic saline to prevent acute kidney injury. Urine output of 200 to 300 mL/h should be maintained with daily serial monitoring of CPK level for to document a downward trend. In case of fluid overload from aggressive fluid resuscitation, loop diuretics may be considered.[1] In severe cases with CPK level > 30,000 IU/L, alkalization of the urine with bicarbonate can be considered.[1][2]
Management of Electrolytes Abnormalities
Rhabdomyolysis is associated with hyperkalemia and hypocalcemia.[1]
Hyperkalemia[1]
- Potassium levels less than 6 mEq/L without EKG changes: managed with potassium binders, and use of bicarbonate in fluids
- Potassium levels 6 mEq/L or above with or without EKG changes: ampule of D50 followed by zero units of regular insulin, and IV sodium bicarbonate.
Hypocalcemia[1]
- Symptomatic hypocalcemia: should be treated with IV calcium gluconate.