Capillary leak syndrome cost-effectiveness of therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Treatment	Mechanism of Action
Endothelial signal transduction
Bevacizumab	Bevacizumab costs in 2014 averaged around $9324 for a total duration of 8 weeks The average price of the drug was $66.60 per 10 mg given at 5 mg given every 2 weeks^[1]
Epoprostenol	Over a two 6-month period, epoprostenol was estimated to cost around $19,483.48. This did not include equipment use of $283.25 which brought the total cost near $19,766.73^[2]
Theophylline + Terbutaline	Due to the risk of toxicity, Theophylline requires increased monitoring. Due to this, costs can average around $121.40 per patient per month ^[3] Compared to other tocolytics, Terbutaline required increased monitoring due to a higher incidence of adverse events resulting in an average cost of $399.02. Comparatively, nifedipine had an average cost of $16.75^[4]
Immune modulation
Corticosteroids
Infliximab
IVIG
Plasmapheresis