Transcortin
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin | |
|---|---|
| Identifiers | |
| Symbol | SERPINA6 |
| Alt. symbols | CBG |
| Entrez | 866 |
| HUGO | 1540 |
| OMIM | 122500 |
| RefSeq | NM_001750 |
| UniProt | P08185 |
| Other data | |
| Locus | Chr. 14 q32.1 |
|
WikiDoc Resources for Transcortin |
|
Articles |
|---|
|
Most recent articles on Transcortin Most cited articles on Transcortin |
|
Media |
|
Powerpoint slides on Transcortin |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Transcortin at Clinical Trials.gov Clinical Trials on Transcortin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Transcortin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Transcortin Discussion groups on Transcortin Patient Handouts on Transcortin Directions to Hospitals Treating Transcortin Risk calculators and risk factors for Transcortin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Transcortin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.
It is an alpha-globulin.
Binding
Transcortin binds several proteins:
- Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
- Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.
Production
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
See also
External links
- Transcortin at the US National Library of Medicine Medical Subject Headings (MeSH)