Alpha 1-antichymotrypsin
| serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | |
|---|---|
| Identifiers | |
| Symbol | SERPINA3 |
| Alt. symbols | AACT |
| Entrez | 12 |
| HUGO | 16 |
| OMIM | 107280 |
| RefSeq | NM_001085 |
| UniProt | P01011 |
| Other data | |
| Locus | Chr. 14 q32.1 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.
It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[1]
Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[1]
This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation.
References
External links
- Alpha+1-antichymotrypsin at the US National Library of Medicine Medical Subject Headings (MeSH)