G12/G13 alpha subunits

guanine nucleotide binding protein (G protein), alpha 13
Identifiers
Symbol	GNA13
Entrez	10672
HUGO	4381
OMIM	604406
RefSeq	NM_006572
UniProt	Q14344
Other data
Locus	Chr. 17 q24

guanine nucleotide binding protein (G protein) alpha 12
Identifiers
Symbol	GNA12
Entrez	2768
HUGO	4380
OMIM	604394
RefSeq	NM_007353
UniProt	Q03113
Other data
Locus	Chr. 7 p22.3

Overview

G12/G13 subunits are alpha units of heterotrimeric G proteins which regulate cell process through the use of guanine nucleotide exchange factors.^[1] These two subunits represent a fourth class of G protein alpha subunits.^[2] They are not sensitive to pertussis toxin.^[3]

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.^[4] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.^[5]

↑ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523.
↑ Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. doi:10.1073/pnas.88.13.5582. PMID 1905812.
↑ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319 ( Pt 1): 165–71. PMID 8870664.
↑ Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J. Biol. Chem. 281 (43): 32660–7. doi:10.1074/jbc.M604588200. PMID 16943201.
↑ Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell. 10 (6): 707–18. doi:10.1016/j.devcel.2006.03.014. PMID 16740474.