CHRNA3
| Cholinergic receptor, nicotinic, alpha 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CHRNA3 ; MGC104879 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 591 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE CHRNA3 210221 at tn.png | |||||||||||
| File:PBB GE CHRNA3 211587 x at tn.png | |||||||||||
| File:PBB GE CHRNA3 211772 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Cholinergic receptor, nicotinic, alpha 3, also known as CHRNA3, is a human gene.[1]
See also
References
Further reading
- Raimondi E, Rubboli F, Moralli D; et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. PMID 1572664.
- Boulter J, O'Shea-Greenfield A, Duvoisin RM; et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster". J. Biol. Chem. 265 (8): 4472–82. PMID 1689727.
- Papke RL, Heinemann SF (1992). "The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors". J. Physiol. (Lond.). 440: 95–112. PMID 1725184.
- Mihovilovic M, Roses AD (1991). "Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor". Exp. Neurol. 111 (2): 175–80. PMID 1989896.
- Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. PMID 2004777.
- Fornasari D, Chini B, Tarroni P, Clementi F (1990). "Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit". Neurosci. Lett. 111 (3): 351–6. PMID 2336208.
- Grando SA, Horton RM, Pereira EF; et al. (1996). "A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes". J. Invest. Dermatol. 105 (6): 774–81. PMID 7490471.
- Rubboli F, Court JA, Sala C; et al. (1995). "Distribution of nicotinic receptors in the human hippocampus and thalamus". Eur. J. Neurosci. 6 (10): 1596–604. PMID 7850023.
- Hiemke C, Stolp M, Reuss S; et al. (1997). "Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes". Neurosci. Lett. 214 (2–3): 171–4. PMID 8878111.
- Elliott KJ, Ellis SB, Berckhan KJ; et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617.
- Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. PMID 9009220.
- Zia S, Ndoye A, Nguyen VT, Grando SA (1998). "Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells". Res. Commun. Mol. Pathol. Pharmacol. 97 (3): 243–62. PMID 9387186.
- Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. PMID 9624109.
- Maus AD, Pereira EF, Karachunski PI; et al. (1998). "Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors". Mol. Pharmacol. 54 (5): 779–88. PMID 9804613.
- Rempel N, Heyers S, Engels H; et al. (1999). "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)". Hum. Genet. 103 (6): 645–53. PMID 9921897.
- Hellström-Lindahl E, Mousavi M, Zhang X; et al. (1999). "Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain". Brain Res. Mol. Brain Res. 66 (1–2): 94–103. PMID 10095081.
- Sato KZ, Fujii T, Watanabe Y; et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. PMID 10336173.
- Flora A, Schulz R, Benfante R; et al. (2000). "Transcriptional regulation of the human alpha5 nicotinic receptor subunit gene in neuronal and non-neuronal tissues". Eur. J. Pharmacol. 393 (1–3): 85–95. PMID 10771001.
- Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes". J. Physiol. (Lond.). 529 Pt 3: 565–77. PMID 11118490.
- Lev-Lehman E, Bercovich D, Xu W; et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4". J. Hum. Genet. 46 (7): 362–6. PMID 11450844.
External links
- CHRNA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.