CHRNA7

Cholinergic receptor, nicotinic, alpha 7
Identifiers
Symbols	CHRNA7 ; NACHRA7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 593
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cholinergic receptor, nicotinic, alpha 7, also known as CHRNA7, is a human gene.

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.

See also

• Nicotinic acetylcholine receptor
• Acetylcholine receptor
• Acetylcholine

See also

• Nicotinic acetylcholine receptor

Further reading

• Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–7. PMID 7571003.
• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.CS1 maint: Multiple names: authors list (link)
• Gallowitsch-Puerta M, Tracey KJ (2006). "Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor". Ann. N. Y. Acad. Sci. 1062: 209–19. doi:10.1196/annals.1358.024. PMID 16461803.
• Peng X, Katz M, Gerzanich V; et al. (1994). "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes". Mol. Pharmacol. 45 (3): 546–54. PMID 8145738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chini B, Raimond E, Elgoyhen AB; et al. (1994). "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)". Genomics. 19 (2): 379–81. doi:10.1006/geno.1994.1075. PMID 8188270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elliott KJ, Ellis SB, Berckhan KJ; et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chavez-Noriega LE, Crona JH, Washburn MS; et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. PMID 9009220.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.CS1 maint: Multiple names: authors list (link)
• Gault J, Robinson M, Berger R; et al. (1998). "Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)". Genomics. 52 (2): 173–85. doi:10.1006/geno.1998.5363. PMID 9782083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Curtis L, Blouin JL, Radhakrishna U; et al. (1999). "No evidence for linkage between schizophrenia and markers at chromosome 15q13-14". Am. J. Med. Genet. 88 (2): 109–12. PMID 10206225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sander T, Schulz H, Vieira-Saeker AM; et al. (1999). "Evaluation of a putative major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q14". Am. J. Med. Genet. 88 (2): 182–7. PMID 10206240.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato KZ, Fujii T, Watanabe Y; et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. PMID 10336173.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang HY, Lee DH, D'Andrea MR; et al. (2000). "beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology". J. Biol. Chem. 275 (8): 5626–32. PMID 10681545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schuller HM, Jull BA, Sheppard BJ, Plummer HK (2000). "Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders". Eur. J. Pharmacol. 393 (1–3): 265–77. PMID 10771023.CS1 maint: Multiple names: authors list (link)
• Kihara T, Shimohama S, Sawada H; et al. (2001). "alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity". J. Biol. Chem. 276 (17): 13541–6. doi:10.1074/jbc.M008035200. PMID 11278378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Freedman R, Leonard S, Gault JM; et al. (2001). "Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)". Am. J. Med. Genet. 105 (1): 20–2. PMID 11424985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Engidawork E, Gulesserian T, Balic N; et al. (2002). "Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 211–22. PMID 11771745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CHRNA7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.