GABRR1
| Gamma-aminobutyric acid (GABA) receptor, rho 1 | |||||||||||
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| Symbols | GABRR1 ; MGC163216 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20470 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Gamma-aminobutyric acid (GABA) receptor, rho 1, also known as GABRR1, is a human gene.[1]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[1]
See also
References
Further reading
- Cutting GR, Curristin S, Zoghbi H; et al. (1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–6. PMID 1315307.
- Cutting GR, Lu L, O'Hara BF; et al. (1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2673–7. PMID 1849271.
- Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors". J. Neurosci. 15 (11): 7684–91. PMID 7472519.
- Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–7. PMID 9153229.
- Kusama T, Hatama K, Sakurai M; et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. PMID 9839716.
- Hanley JG, Koulen P, Bedford F; et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.
- Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–12. PMID 10542332.
- Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". J. Biol. Chem. 275 (2): 840–6. PMID 10625616.
- Filippova N, Sedelnikova A, Zong Y; et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.". Mol. Pharmacol. 57 (5): 847–56. PMID 10779366.
- Billups D, Hanley JG, Orme M; et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
- Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes". Biomed. Environ. Sci. 14 (4): 269–77. PMID 11862606.
- Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–46. PMID 12175859.
- Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening". J. Biol. Chem. 277 (46): 43741–8. doi:10.1074/jbc.M202007200. PMID 12226075.
- Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Boué-Grabot E, Emerit MB, Toulmé E; et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627.
- Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism". Arch. Med. Res. 35 (3): 194–8. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459.
- Sedelnikova A, Smith CD, Zakharkin SO; et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model". J. Biol. Chem. 280 (2): 1535–42. doi:10.1074/jbc.M409908200. PMID 15548535.
- Song XQ, Meng F, Ramsey DJ; et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina". Neuroscience. 136 (2): 467–75. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491.
External links
- GABRR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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