P2RX7

Purinergic receptor P2X, ligand-gated ion channel, 7
Identifiers
Symbols	P2RX7 ; MGC20089; P2X7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1925
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE P2RX7 207091 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Purinergic receptor P2X, ligand-gated ion channel, 7, also known as P2RX7, is a human gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.

See also

• Purinergic receptor
• P2X receptor

Further reading

• Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA. (2003). "P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation". Crit Rev Eukaryot Gene Expr. 13 (2–4): 237–42. PMID 14696970.CS1 maint: Multiple names: authors list (link)
• Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003). "Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro". Calcif Tissue Int. 72 (4): 361–9. PMID 12874700.CS1 maint: Multiple names: authors list (link)
• Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G, Gallagher JA. "Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling". Bone. 28 (5): 507–12. PMID 11344050.CS1 maint: Multiple names: authors list (link)
• Gartland A, Hipskind RA, Gallagher JA, Bowler WB. (2001). "Expression of a P2X7 receptor by a subpopulation of human osteoblasts". J Bone Miner Res . 16 (5): 846–56. PMID 11341329.CS1 maint: Multiple names: authors list (link)
• Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. (2003). "Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice". Crit Rev Eukaryot Gene Expr. 13 (2–4): 243–53. PMID 14696971.CS1 maint: Multiple names: authors list (link)
• North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Rassendren F, Buell GN, Virginio C; et al. (1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA". J. Biol. Chem. 272 (9): 5482–6. PMID 9038151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buell GN, Talabot F, Gos A; et al. (1999). "Gene structure and chromosomal localization of the human P2X7 receptor". Recept. Channels. 5 (6): 347–54. PMID 9826911.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu BJ, Zhang W, Worthington RA; et al. (2001). "A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor". J. Biol. Chem. 276 (14): 11135–42. doi:10.1074/jbc.M010353200. PMID 11150303.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim M, Jiang LH, Wilson HL; et al. (2002). "Proteomic and functional evidence for a P2X7 receptor signalling complex". EMBO J. 20 (22): 6347–58. doi:10.1093/emboj/20.22.6347. PMID 11707406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Worthington RA, Smart ML, Gu BJ; et al. (2002). "Point mutations confer loss of ATP-induced human P2X(7) receptor function". FEBS Lett. 512 (1–3): 43–6. PMID 11852049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiley JS, Dao-Ung LP, Gu BJ; et al. (2002). "A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study". Lancet. 359 (9312): 1114–9. PMID 11943260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilson HL, Wilson SA, Surprenant A, North RA (2002). "Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus". J. Biol. Chem. 277 (37): 34017–23. doi:10.1074/jbc.M205120200. PMID 12107182.CS1 maint: Multiple names: authors list (link)
• Atkinson L, Milligan CJ, Buckley NJ, Deuchars J (2002). "An ATP-gated ion channel at the cell nucleus". Nature. 420 (6911): 42. doi:10.1038/420042a. PMID 12422208.CS1 maint: Multiple names: authors list (link)
• Budagian V, Bulanova E, Brovko L; et al. (2003). "Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B.". J. Biol. Chem. 278 (3): 1549–60. doi:10.1074/jbc.M206383200. PMID 12424250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sluyter R, Wiley JS (2003). "Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors". Int. Immunol. 14 (12): 1415–21. PMID 12456589.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiley JS, Dao-Ung LP, Li C; et al. (2003). "An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor". J. Biol. Chem. 278 (19): 17108–13. doi:10.1074/jbc.M212759200. PMID 12586825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barden JA, Sluyter R, Gu BJ, Wiley JS (2003). "Specific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytes". FEBS Lett. 538 (1–3): 159–62. PMID 12633871.CS1 maint: Multiple names: authors list (link)
• Verhoef PA, Estacion M, Schilling W, Dubyak GR (2003). "P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release". J. Immunol. 170 (11): 5728–38. PMID 12759456.CS1 maint: Multiple names: authors list (link)
• Greig AV, Linge C, Terenghi G; et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. PMID 12787128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denlinger LC, Sommer JA, Parker K; et al. (2003). "Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function". J. Immunol. 171 (3): 1304–11. PMID 12874219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• P2RX7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.