RAC1

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
File:PBB Protein RAC1 image.jpg PDB rendering based on 1ds6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ds6​, 1e96​, 1foe​, 1g4u​, 1he1​, 1hh4​, 1i4d​, 1i4l​, 1i4t​, 1mh1​, 1ryf​, 1ryh​, 2c2h​, 2fju​, 2g0n​, 2h7v​, 2ic5​, 2nz8​, 2ov2​, 2p2l​
Identifiers
Symbols	RAC1 ; MGC111543; MIG5; TC-25; p21-Rac1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69035
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAC1 208640 at tn.png
File:PBB GE RAC1 208641 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), also known as RAC1, is a human gene. Rac1 belongs to the Rho family of GTPases. It is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Further reading

• Benitah SA, Frye M, Glogauer M, Watt FM (2005). "Stem cell depletion through epidermal deletion of Rac1". Science. 309 (5736): 933–5. doi:10.1126/science.1113579. PMID 16081735.CS1 maint: Multiple names: authors list (link)
• Dorseuil O, Gacon G (1997). "[Signal transduction by Rac small G proteins in phagocytes]". C. R. Seances Soc. Biol. Fil. 191 (2): 237–46. PMID 9255350.
• Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition". Trends Neurosci. 25 (4): 191–9. PMID 11998687.

External links

• rac1+GTP-Binding+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)