SERPINB4
| Serpin peptidase inhibitor, clade B (ovalbumin), member 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SERPINB4 ; SCCA1; LEUPIN; PI11; SCCA-2; SCCA2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 74456 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SERPINB4 209720 s at tn.png | |||||||||||
| File:PBB GE SERPINB4 209719 x at tn.png | |||||||||||
| File:PBB GE SERPINB4 210413 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Serpin peptidase inhibitor, clade B (ovalbumin), member 4, also known as SERPINB4, is a human gene.[1]
See also
References
Further reading
- Barnes RC, Worrall DM (1995). "Identification of a novel human serpin gene; cloning sequencing and expression of leupin". FEBS Lett. 373 (1): 61–5. PMID 7589435.
- Schneider SS, Schick C, Fish KE; et al. (1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3147–51. PMID 7724531.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Bartuski AJ, Kamachi Y, Schick C; et al. (1999). "A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases". Genomics. 54 (2): 297–306. doi:10.1006/geno.1998.5586. PMID 9828132.
- Sakaguchi Y, Kishi F, Murakami A; et al. (1999). "Structural analysis of human SCC antigen 2 promoter". Biochim. Biophys. Acta. 1444 (1): 111–6. PMID 9931463.
- Cataltepe S, Gornstein ER, Schick C; et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". J. Histochem. Cytochem. 48 (1): 113–22. PMID 10653592.
- Luke C, Schick C, Tsu C; et al. (2000). "Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage". Biochemistry. 39 (24): 7081–91. PMID 10852705.
- Uemura Y, Pak SC, Luke C; et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer. 89 (4): 368–77. PMID 10956412.
- Hamada K, Shinomiya H, Asano Y; et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta. 1518 (1–2): 124–31. PMID 11267667.
- Takeda A, Kajiya A, Iwasawa A; et al. (2003). "Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis". Biol. Chem. 383 (7–8): 1231–6. PMID 12437110.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gariboldi M, Peissel B, Fabbri A; et al. (2003). "SCCA2-like serpins mediate genetic predisposition to skin tumors". Cancer Res. 63 (8): 1871–5. PMID 12702576.
- Sakata Y, Arima K, Takai T; et al. (2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1". J. Biol. Chem. 279 (7): 5081–7. doi:10.1074/jbc.M311585200. PMID 14630915.
- Pontisso P, Calabrese F, Benvegnù L; et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". Br. J. Cancer. 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMID 14970861.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ray R, Choi M, Zhang Z; et al. (2005). "Uteroglobin suppresses SCCA gene expression associated with allergic asthma". J. Biol. Chem. 280 (11): 9761–4. doi:10.1074/jbc.C400581200. PMID 15677460.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sueoka K, Nawata S, Nakagawa T; et al. (2005). "Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines". Int. J. Oncol. 27 (5): 1345–53. PMID 16211231.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Katagiri C, Nakanishi J, Kadoya K, Hibino T (2006). "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase". J. Cell Biol. 172 (7): 983–90. doi:10.1083/jcb.200508064. PMID 16549498.
External links
- SERPINB4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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