Aplastic anemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Aplastic anemia is seen as a result of hypoplastic bone marrow causing pancytopenia (anemia, neutropenia, thrombocytopenia). The history and symptoms seen are secondary to these abnormalities.
Symptoms
- Malaise, fatigue, and pallor (Anemia)
- Increased risk of hemorrhage, bruising, and menorrhagia (thrombocytopenia).
- Increased risk of infection (leukopenia)
Diagnosis and management of aplastic anemia [1] (DONOT EDIT)
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Diagnosis and Evaluation of aplastic anemiaCareful history and clinical examination Detailed drug and occupational exposure history Patients presenting with aplastic anaemia should be assessed to: Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow Classify the disease severity using standard blood and bone marrow criteria Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones Exclude a possible late onset inherited bone marrow failure disorder Multidisciplinary approach Referral to specialist if necessary |
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For ACC/AHA Level of evidence and classes click here.
References
- ↑ Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.