Loeffler syndrome
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| Loeffler's syndrome | |
| Classification and external resources | |
| ICD-10 | J82 |
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| ICD-9 | 518.3 |
| DiseasesDB | 7580 |
| MedlinePlus | 000105 |
| MeSH | D011657 |
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Löffler's syndrome Microchapters |
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Loeffler syndrome On the Web |
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American Roentgen Ray Society Images of Loeffler syndrome |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Synonyms and keywords: Löffler's syndrome; pulmonary infiltrates with eosinophilia; simple pulmonary eosinophilia; cryptogenic eosinophilic pneumonia;
Löffler disease; Loffler pneumonia
Historical perspective
It was first described in 1932 by Wilhelm Löffler[1] in cases of eosinophilic pneumonia caused by the parasites Ascaris lumbricoides,[2] Strongyloides stercoralis and the hookworms Ancylostoma duodenale and Necator americanus.
Pathophysiology
Infecting larvae reach the lungs via the bloodstream, penetrate into alveoli, and ascend the airways before descending the alimentary tract into the small bowel. Alveolar penetration triggers off an allergic reaction leading to pulmonary eosinophilia.
Causes
References
- ↑ Löffler, W. (1932). "Zur Differential-Diagnose der Lungenifiltrierungen. I. Frühfiltrate unter besonerer Berücksichtigung der Rückbildungszeiten". Beiträge zum Klinik der Tuberkulose. 79: 338–367.
Löffler, W. (1932). "Zur Differential-Diagnose der Lungenifiltrierungen. II. Über flüchtige Succedan-Infiltrate (mit Eosinophilie)". Beiträge zum Klinik der Tuberkulose. 79: 368–382.
Löffler, W. (1935). "Flüchtige Lungeninfiltrate mit Eosinophilia". Klinische Wochjenschrift. Berlin. 14 (9): 297–9. doi:10.1007/BF01782394. - ↑ Template:GPnotebook