Polymyalgia rheumatica causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
The cause of this disorder is unknown; however, studies have shown that during this disorder, the white blood cells in the body attack the lining of muscle joints, causing inflammation. Recent studies have found that inherited factors also play a role in the probability that an individual will become sick with polymyalgia rheumatica. Several theories have included viral stimulation of the immune system in genetically susceptible individuals.
Manifestation of gaintcell arteritis as polymyalgia rheumatica is associated with the increased frequency of HLA DR4.[1].PMR and GCA also share the associated sequence polymorphism encoded by the second hypervariable region(HVR) of the HLA DRB1 gene unlike rheumatoid arthritis in which the sequence is encoded by third HVR.[2]. Isolated PMR has positive association with TNFb3, independent of HLA DRB1 association.[3]
Several viruses are thought to be linked to polymyalgia rheumatica,including the adenovirus, which causes respiratory infections; the human parvovirus B19, an infection that affects children; and the human parainfluenza virus.
References
- ↑ Cid MC, Ercilla G, Vilaseca J; et al. (1988). "Polymyalgia rheumatica: a syndrome associated with HLA-DR4 antigen". Arthritis Rheum. 31 (5): 678–82. PMID 3259885. Unknown parameter
|month=ignored (help) - ↑ Weyand CM, Hunder NN, Hicok KC, Hunder GG, Goronzy JJ (1994). "HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis". Arthritis Rheum. 37 (4): 514–20. PMID 8147928. Unknown parameter
|month=ignored (help) - ↑ Mattey DL, Hajeer AH, Dababneh A; et al. (2000). "Association of giant cell arteritis and polymyalgia rheumatica with different tumor necrosis factor microsatellite polymorphisms". Arthritis Rheum. 43 (8): 1749–55. doi:10.1002/1529-0131(200008)43:8<1749::AID-ANR11>3.0.CO;2-K. PMID 10943865. Unknown parameter
|month=ignored (help)