Hypertensive nephropathy overview
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Hypertensive nephropathy Microchapters |
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Differentiating Hypertensive Nephropathy from other Diseases |
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Diagnosis |
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Hypertensive nephropathy overview On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Overview
Hypertensive nephropathy is a medical condition referring to damage to the kidney due to chronic high blood pressure.
It should be distinguished from "renovascular hypertension" (I15.0), which is a form of secondary hypertension.
In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumens — hyaline arteriolosclerosis. Consequent ischemia will produce tubular atrophy, interstitial fibrosis, glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and periglomerular fibrosis. In advanced stages, renal failure will occur. Functional nephrons have dilated tubules, often with hyaline casts in the lumens.