Alzheimer's disease ultrasound
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Focused ultrasound is a non-invasive, therapeutic technology aiming to improve the quality of life at lower costs for patients with Alzheimer’s disease.
Echocardiography/Ultrasound
Focused Ultrasound Therapy: [1] [2] [3] [4]
- Non-invasive, therapeutic technology aiming to improve the quality of life with lower costs for patients with Alzheimer’s disease.
- Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
- Ultrasound produces a variety of therapeutic effects eliminating the need for incisions or radiation at the focus where beams converge.
- Preclinical studies have have shown promising results with the potential of focused ultrasound in enhancing the delivery of therapeutic drugs or antibodies to the brain.
- Focused ultrasound in combination with microbubbles can safely open the blood-brain barrier (BBB) thereby enabling enhanced delivery of anti-amyloid antibodies to the brain. This method may reduce the number of plaques and improve cognition in Alzheimer’s disease subjects.
References
- ↑ Miller DB, O'Callaghan JP (2017). "New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases". Metabolism. 69S: S3–S7. doi:10.1016/j.metabol.2017.01.012. PMID 28159329.
- ↑ Galkin MV (2016). "[The use of transcranial focused ultrasound in CNS diseases]". Zh Vopr Neirokhir Im N N Burdenko. 80 (2): 108–118. doi:10.17116/neiro2016802108-118. PMID 27331236.
- ↑ Jolesz FA (2014). "Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease?". Radiology. 273 (3): 631–3. doi:10.1148/radiol.14142033. PMID 25420161.
- ↑ Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K (2014). "Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy". J Control Release. 192: 243–8. doi:10.1016/j.jconrel.2014.07.051. PMID 25107692.