Atopic dermatitis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogechukwu Hannah Nnabude, MD; Shalinder Singh, M.B.B.S.[2]

Overview

There is no established system for the classification of atopic dermatitis. It may be classified into intrinsic atopic dermatitis and extrinsic atopic dermatitis according to the means of allergic sensitization. Intrinsic atopic dermatitis is associated with normal serum IgE levels vs elevated total serum IgE levels.

Classification

There is no established system for the classification of atopic dermatitis.

Atopic dermatitis may be classified according to the means of allergic sensitization into:^[1]^[2]

Intrinsic atopic dermatitis
Extrinsic atopic dermatitis

Intrinsic atopic dermatitis	Extrinsic atopic dermatitis
Normal serum IgE levels^[3] No specific IgE sensitization against^[4] Environmental allergens Food allergens Skin prick tests No filaggrin mutation Relative lower levels of IL-4 and IL-13^[5] Normal eosinophil counts and eosinophil cationic protein levels^[6]	Elevated total serum IgE levels^[7] IgE sensitization against^[8] Environmental allergens Food allergens Skin prick tests Filaggrin mutations may be present^[9] Increased levels of IL-4, IL-5 and IL-13 Increased eosinophil counts and eosinophil cationic protein levels^[10]

References

↑ Novak N, Bieber T (August 2003). "Allergic and nonallergic forms of atopic diseases". J. Allergy Clin. Immunol. 112 (2): 252–62. PMID 12897728.
↑ Karimkhani C, Silverberg JI, Dellavalle RP (June 2015). "Defining intrinsic vs. extrinsic atopic dermatitis". Dermatol. Online J. 21 (6). PMID 26158358.
↑ Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.
↑ Wüthrich B, Schmid-Grendelmeier P (2003). "The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS". J Investig Allergol Clin Immunol. 13 (1): 1–5. PMID 12861844.
↑ Suárez-Fariñas M, Dhingra N, Gittler J, Shemer A, Cardinale I, de Guzman Strong C, Krueger JG, Guttman-Yassky E (August 2013). "Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis". J. Allergy Clin. Immunol. 132 (2): 361–70. doi:10.1016/j.jaci.2013.04.046. PMC 3991240. PMID 23777851.
↑ Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.
↑ Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.
↑ Wüthrich B, Schmid-Grendelmeier P (2003). "The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS". J Investig Allergol Clin Immunol. 13 (1): 1–5. PMID 12861844.
↑ Weidinger S, Rodríguez E, Stahl C, Wagenpfeil S, Klopp N, Illig T, Novak N (March 2007). "Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis". J. Invest. Dermatol. 127 (3): 724–6. doi:10.1038/sj.jid.5700630. PMID 17096018.
↑ Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.

[pmid12897728-1] Novak N, Bieber T (August 2003). "Allergic and nonallergic forms of atopic diseases". J. Allergy Clin. Immunol. 112 (2): 252–62. PMID 12897728.

[pmid26158358-2] Karimkhani C, Silverberg JI, Dellavalle RP (June 2015). "Defining intrinsic vs. extrinsic atopic dermatitis". Dermatol. Online J. 21 (6). PMID 26158358.

[pmid16965428-3] Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.

[pmid12861844-4] Wüthrich B, Schmid-Grendelmeier P (2003). "The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS". J Investig Allergol Clin Immunol. 13 (1): 1–5. PMID 12861844.

[pmid23777851-5] Suárez-Fariñas M, Dhingra N, Gittler J, Shemer A, Cardinale I, de Guzman Strong C, Krueger JG, Guttman-Yassky E (August 2013). "Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis". J. Allergy Clin. Immunol. 132 (2): 361–70. doi:10.1016/j.jaci.2013.04.046. PMC 3991240. PMID 23777851.

[pmid169654283-6] Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.

[pmid169654282-7] Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.

[pmid128618442-8] Wüthrich B, Schmid-Grendelmeier P (2003). "The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS". J Investig Allergol Clin Immunol. 13 (1): 1–5. PMID 12861844.

[pmid17096018-9] Weidinger S, Rodríguez E, Stahl C, Wagenpfeil S, Klopp N, Illig T, Novak N (March 2007). "Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis". J. Invest. Dermatol. 127 (3): 724–6. doi:10.1038/sj.jid.5700630. PMID 17096018.

[pmid169654284-10] Park JH, Choi YL, Namkung JH, Kim WS, Lee JH, Park HJ, Lee ES, Yang JM (October 2006). "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables". Br. J. Dermatol. 155 (4): 778–83. doi:10.1111/j.1365-2133.2006.07394.x. PMID 16965428.

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Atopic dermatitis classification

Overview

Classification

References

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