Edoxudine

Edoxudine
Clinical data
ATC code	D06BB09 (WHO) ;
Identifiers
	IUPAC name 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;
CAS Number	15176-29-1 ;
PubChem CID	66377;
ChemSpider	59752 ;
UNII	15ZQM81Y3R;
ChEMBL	ChEMBL318153 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C11H16N2O5
Molar mass	256.25514
3D model (JSmol)	Interactive image;
	SMILES O=C/1NC(=O)N(\C=C\1CC)[C@@H]2O[C@@H]([C@@H](O)C2)CO;
	InChI InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1 ; Key:XACKNLSZYYIACO-DJLDLDEBSA-N ;
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Edoxudine (or edoxudin) is an Antiviral drug. It is an analog of thymidine, a nucleoside.

It has shown effectiveness against herpes simplex virus.^[1]

Synthesis

Bergstrom, Donald E.; Ruth, Jerry L. (1976). "Synthesis of C-5 substituted pyrimidine nucleosides via organopalladium intermediates". Journal of the American Chemical Society. 98 (6): 1587–9. doi:10.1021/ja00422a056. PMID 1249369.

References

↑ "Topical antiviral agents for herpes simplex virus infections". Drugs Today. 34 (12): 1013–25. December 1998. doi:10.1358/dot.1998.34.12.487486. PMID 14743269.

Template:Antiinfective-drug-stub Template:Dermatologic-drug-stub

[1] "Topical antiviral agents for herpes simplex virus infections". Drugs Today. 34 (12): 1013–25. December 1998. doi:10.1358/dot.1998.34.12.487486. PMID 14743269.

[1]

v t e Antibiotics and chemotherapeutics for dermatological use (D06)
Antibiotics: tetracycline and derivatives	Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline
Antibiotics: other	Fusidic acid - Chloramphenicol - Neomycin - Bacitracin - Gentamicin - Tyrothricin - Mupirocin - Nadifloxacin - Virginiamycin - Rifaximin - Amikacin
Chemotherapeutics: sulfonamides	Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine
Chemotherapeutics: antivirals	Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol
Chemotherapeutics: other	Metronidazole

Clinical data

ATC code	D06BB09 (WHO)
Identifiers
IUPAC name 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
CAS Number	15176-29-1^Y
PubChem CID	66377
ChemSpider	59752^N
UNII	15ZQM81Y3R
ChEMBL	ChEMBL318153^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₁H₁₆N₂O₅
Molar mass	256.25514
3D model (JSmol)	Interactive image
SMILES O=C/1NC(=O)N(\C=C\1CC)[C@@H]2O[C@@H]([C@@H](O)C2)CO
InChI InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1^N Key:XACKNLSZYYIACO-DJLDLDEBSA-N^N
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Edoxudine

Synthesis

References

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