Follicular lymphoma causes
Jump to navigation
Jump to search
|
Follicular lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Follicular lymphoma causes On the Web |
|
American Roentgen Ray Society Images of Follicular lymphoma causes |
|
Risk calculators and risk factors for Follicular lymphoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Follicular lymphoma may be caused by a translocation between chromosome 14 and 18 that results in the overexpression of the BCL-2 gene.
Causes
- A translocation between chromosome 14 and 18 results in the overexpression of the BCL-2 gene.[1]
- As the bcl-2 protein is normally involved in preventing apoptosis, cells with overexpression of this protein are basically immortal.
- The BCL-2 gene is normally found on chromosome 18, and the translocation moves the gene near to the site of the immunoglobulin heavy chain enhancer element on chromosome 14.
- Translocations of BCL6 at 3q27 may also be involved.[2]
References
- ↑ Bosga-Bouwer AG, van Imhoff GW, Boonstra R; et al. (February 2003). "Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive". Blood. 101 (3): 1149–54. doi:10.1182/blood.V101.3.1149. PMID 12529293.
- ↑ Bosga-Bouwer AG, Haralambieva E, Booman M; et al. (November 2005). "BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B". Genes Chromosomes Cancer. 44 (3): 301–4. doi:10.1002/gcc.20246. PMID 16075463.