Follicular lymphoma diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Laboratory tests for the diagnosis of follicular lymphoma include lymph node biopsy, complete blood count (CBC), blood chemistry studies, cytogenetics studies, flow cytometry, immunohistochemistry, FISH, genetic testing, and immunophenotyping. CT, MRI, and PET may be helpful in the diagnosis and assessing the spread of follicular lymphoma. Other diagnostic studies for the diagnosis of follicular lymphoma include bone marrow aspiration and biopsy, laparoscopy, and laparotomy.
Diagnostic Study of Choice
- Lymph node biopsy is the diagnostic study of choice[1][2][3].
- Histopathological, Immunohistochemistry, FISh and cytogenetic studies are conducted on the tissue sample.
- Other diagnostic tests that are done are :
- Complete blood count (CBC)
- Complete metabolic panel
- HBV, HCV and HIV testing
- Serum LDH levels and serum β2-microglobulin levels.
- Bone marrow biopsy and aspiration
- Chest x ray and abdominal ultrasound
- CT scan
- PET scan
- Cytogenetics studies
- Flow cytometry
- Immunohistochemistry
- FISH
- Genetic testing
- Immunophenotyping: BCL-2+, BCL6+, CD5-, CD10+, CD19, CD20, CD22, CD43, CD79a, heavy and light chains rearranged, t(14;18)(q32:q21)-85% with rearrangement of BCL-2 gene.
- Endoscopy for gastrointestinal lymphoma[4]
References
- ↑ Ganapathi KA, Pittaluga S, Odejide OO, Freedman AS, Jaffe ES (2014). "Early lymphoid lesions: conceptual, diagnostic and clinical challenges". Haematologica. 99 (9): 1421–32. doi:10.3324/haematol.2014.107938. PMC 4562530. PMID 25176983.
- ↑ Freedman A (2018). "Follicular lymphoma: 2018 update on diagnosis and management". Am J Hematol. 93 (2): 296–305. doi:10.1002/ajh.24937. PMID 29314206.
- ↑ "Guidelines for the diagnosis and treatment of follicular lymphoma in China". Cancer Biol Med. 10 (1): 36–42. 2013. doi:10.7497/j.issn.2095-3941.2013.01.006. PMC 3643683. PMID 23691443.
- ↑ Iwamuro M, Kondo E, Takata K, Yoshino T, Okada H (2016). "Diagnosis of follicular lymphoma of the gastrointestinal tract: A better initial diagnostic workup". World J Gastroenterol. 22 (4): 1674–83. doi:10.3748/wjg.v22.i4.1674. PMC 4721998. PMID 26819532.