Peutz-Jeghers syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
The hallmark of Peutz-Jeghers syndrome is hamatomatous polyps. A positive history of mucucutaneous hyperpigmentation and rectal bleeding is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include abdominal pain, fatigue, and weight loss.
History and Symptoms
Individuals with Peutz-Jeghers syndrome may have positive history of:[1]
- Peutz-Jeghers syndrome in family
- Mucucutaneous hyperpigmentation of the oral mucosa
- Rectal bleeds
- Abdominal pain
- Fatigue
Symptoms of Peutz-Jeghers syndrome include the following:[1][2][3]
- Mucocutaneous hyperpigmentation (mouth, hands, and feet)
- Rectal bleeding
- Melena
- Rectal prolapse
- Abdominal pain
- Weight loss
- Gynecomastia in males
- Menstrual irregularities in females
- Hematemesis
- Fatigue
| Percentage of symptom occurrence in Peutz-Jeghers syndrome | |
|---|---|
| Symptoms | Percentage (%) |
| Abnormal Pigmentation | 80 to 90 |
| GI Bleeding | 30 to 79 |
| Abdominal Pain | 5 to 29 |
References
- ↑ 1.0 1.1 Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). "Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach". World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.
- ↑ Giardiello, F; Trimbath, J (2006). "Peutz-Jeghers Syndrome and Management Recommendations". Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.
- ↑ "Peutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".