SLC22A6

Solute carrier family 22 (organic anion transporter), member 6
Identifiers
Symbols	SLC22A6 ; OAT1; HOAT1; MGC45260; PAHT; ROAT1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 16813
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC22A6 210343 s at tn.png
File:PBB GE SLC22A6 216599 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 22 (organic anion transporter), member 6, also known as SLC22A6, is a human gene.

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Five transcript variants encoding five different isoforms have been found for this gene.

See also

• Solute carrier family

Further reading

• Reid G, Wolff NA, Dautzenberg FM, Burckhardt G (1999). "Cloning of a human renal p-aminohippurate transporter, hROAT1". Kidney Blood Press. Res. 21 (2–4): 233–7. PMID 9762842.CS1 maint: Multiple names: authors list (link)
• Hosoyamada M, Sekine T, Kanai Y, Endou H (1999). "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney". Am. J. Physiol. 276 (1 Pt 2): F122–8. PMID 9887087.CS1 maint: Multiple names: authors list (link)
• Lu R, Chan BS, Schuster VL (1999). "Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.". Am. J. Physiol. 276 (2 Pt 2): F295–303. PMID 9950961.CS1 maint: Multiple names: authors list (link)
• Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)". Biochem. Biophys. Res. Commun. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.CS1 maint: Multiple names: authors list (link)
• Cihlar T, Lin DC, Pritchard JB; et al. (1999). "The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1". Mol. Pharmacol. 56 (3): 570–80. PMID 10462545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bahn A, Prawitt D, Buttler D; et al. (2000). "Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene". Biochem. Biophys. Res. Commun. 275 (2): 623–30. doi:10.1006/bbrc.2000.3230. PMID 10964714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Babu E, Takeda M, Narikawa S; et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. PMID 11855680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burckhardt BC, Brai S, Wallis S; et al. (2003). "Transport of cimetidine by flounder and human renal organic anion transporter 1". Am. J. Physiol. Renal Physiol. 284 (3): F503–9. doi:10.1152/ajprenal.00290.2002. PMID 12429554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichida K, Hosoyamada M, Kimura H; et al. (2004). "Urate transport via human PAH transporter hOAT1 and its gene structure". Kidney Int. 63 (1): 143–55. doi:10.1046/j.1523-1755.2003.00710.x. PMID 12472777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolff NA, Thies K, Kuhnke N; et al. (2004). "Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization". J. Am. Soc. Nephrol. 14 (8): 1959–68. PMID 12874449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sauvant C, Hesse D, Holzinger H; et al. (2004). "Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells". Am. J. Physiol. Renal Physiol. 286 (4): F774–83. doi:10.1152/ajprenal.00326.2003. PMID 14644751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka K, Xu W, Zhou F, You G (2004). "Role of glycosylation in the organic anion transporter OAT1". J. Biol. Chem. 279 (15): 14961–6. doi:10.1074/jbc.M400197200. PMID 14749323.CS1 maint: Multiple names: authors list (link)
• Sakurai Y, Motohashi H, Ueo H; et al. (2004). "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases". Pharm. Res. 21 (1): 61–7. PMID 14984259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bahn A, Ebbinghaus C, Ebbinghaus D; et al. (2005). "Expression studies and functional characterization of renal human organic anion transporter 1 isoforms". Drug Metab. Dispos. 32 (4): 424–30. doi:10.1124/dmd.32.4.424. PMID 15039295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong M, Zhou F, You G (2004). "Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1". J. Biol. Chem. 279 (30): 31478–82. doi:10.1074/jbc.M404686200. PMID 15145940.CS1 maint: Multiple names: authors list (link)
• Zalups RK, Aslamkhan AG, Ahmad S (2005). "Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury". Kidney Int. 66 (1): 251–61. doi:10.1111/j.1523-1755.2004.00726.x. PMID 15200431.CS1 maint: Multiple names: authors list (link)
• Zalups RK, Ahmad S (2004). "Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1". J. Am. Soc. Nephrol. 15 (8): 2023–31. doi:10.1097/01.ASN.0000135115.63412.A9. PMID 15284288.
• Fujita T, Brown C, Carlson EJ; et al. (2005). "Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)". Pharmacogenet. Genomics. 15 (4): 201–9. PMID 15864112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.