SLC29A1

Solute carrier family 29 (nucleoside transporters), member 1
Identifiers
Symbols	SLC29A1 ; ENT1; MGC1465; MGC3778
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37985
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC29A1 201801 s at tn.png
File:PBB GE SLC29A1 201802 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 29 (nucleoside transporters), member 1, also known as SLC29A1, is a human gene.

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Griffiths M, Beaumont N, Yao SY; et al. (1997). "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs". Nat. Med. 3 (1): 89–93. PMID 8986748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coe IR, Griffiths M, Young JD; et al. (1998). "Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2". Genomics. 45 (2): 459–60. doi:10.1006/geno.1997.4928. PMID 9344680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Griffiths M, Yao SY, Abidi F; et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta". Biochem. J. 328 ( Pt 3): 739–43. PMID 9396714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lum PY, Ngo LY, Bakken AH, Unadkat JD (2000). "Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles". Cancer Chemother. Pharmacol. 45 (4): 273–8. PMID 10755314.CS1 maint: Multiple names: authors list (link)
• Sundaram M, Yao SY, Ingram JC; et al. (2002). "Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs". J. Biol. Chem. 276 (48): 45270–5. doi:10.1074/jbc.M107169200. PMID 11584005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• SenGupta DJ, Lum PY, Lai Y; et al. (2002). "A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine". Biochemistry. 41 (5): 1512–9. PMID 11814344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao SY, Ng AM, Vickers MF; et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galmarini CM, Thomas X, Calvo F; et al. (2002). "Potential mechanisms of resistance to cytarabine in AML patients". Leuk. Res. 26 (7): 621–9. PMID 12008078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333.CS1 maint: Multiple names: authors list (link)
• Sankar N, Machado J, Abdulla P; et al. (2002). "Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity". Nucleic Acids Res. 30 (20): 4339–50. PMID 12384580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reiman T, Clarke ML, Dabbagh L; et al. (2003). "Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease". Leuk. Lymphoma. 43 (7): 1435–40. PMID 12389626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.CS1 maint: Multiple names: authors list (link)
• Szkotak AJ, Ng AM, Man SF; et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. PMID 12820662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai Y, Tse CM, Unadkat JD (2004). "Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs". J. Biol. Chem. 279 (6): 4490–7. doi:10.1074/jbc.M307938200. PMID 14607828.CS1 maint: Multiple names: authors list (link)
• Lehner B, Semple JI, Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. PMID 14667819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1". Biochem. J. 380 (Pt 1): 131–7. doi:10.1042/BJ20031880. PMID 14759222.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)