KIF1B: Difference between revisions

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{{Infobox_gene}}
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'''Kinesin-like protein KIF1B''' is a [[protein]] that in humans is encoded by the ''KIF1B'' [[gene]].<ref name="pmid11389829">{{cite journal |vauthors=Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N | title = Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta | journal = Cell | volume = 105 | issue = 5 | pages = 587–97 |date=Jun 2001 | pmid = 11389829 | pmc = | doi =10.1016/S0092-8674(01)00363-4 }}</ref><ref name="pmid10762626">{{cite journal |vauthors=Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A | title = Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2 | journal = Int J Oncol | volume = 16 | issue = 5 | pages = 907–16 |date=May 2000 | pmid = 10762626 | pmc =  | doi =  10.3892/ijo.16.5.907}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIF1B kinesin family member 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23095| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Kinesin family member 1B
| HGNCid = 16636
| Symbol = KIF1B
| AltSymbols =; CMT2; CMT2A; CMT2A1; FLJ23699; HMSNII; KIAA0591; KIAA1448; KLP; MGC134844
| OMIM = 605995
| ECnumber = 
| Homologene = 69177
| MGIid = 108426
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0019894 |text = kinesin binding}}
  | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0030659 |text = cytoplasmic vesicle membrane}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0007270 |text = nerve-nerve synaptic transmission}} {{GNF_GO|id=GO:0007274 |text = neuromuscular synaptic transmission}} {{GNF_GO|id=GO:0008089 |text = anterograde axon cargo transport}} {{GNF_GO|id=GO:0009790 |text = embryonic development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23095
    | Hs_Ensembl = ENSG00000054523
    | Hs_RefseqProtein = NP_055889
    | Hs_RefseqmRNA = NM_015074
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 10193418
    | Hs_GenLoc_end = 10364248
    | Hs_Uniprot = O60333
    | Mm_EntrezGene = 16561
    | Mm_Ensembl = ENSMUSG00000063077
    | Mm_RefseqmRNA = NM_008441
    | Mm_RefseqProtein = NP_032467
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 148020119
    | Mm_GenLoc_end = 148151498
    | Mm_Uniprot = Q6PB45
  }}
}}
'''Kinesin family member 1B''', also known as '''KIF1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIF1B kinesin family member 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23095| accessdate = }}</ref>


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==Clinical significance==
It is associated with [[Charcot–Marie–Tooth disease]], type 2A1.<ref name="entrez" />
==Interactions==
KIF1B has been shown to [[Protein-protein interaction|interact]] with [[GIPC1]].<ref name=pmid10198040>{{cite journal |last=Bunn |first=R C |authorlink= |author2=Jensen M A |author3=Reed B C  |date=Apr 1999|title=Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton |journal=Mol. Biol. Cell |volume=10 |issue=4 |pages=819–32 | issn = 1059-1524| pmid = 10198040 | pmc = 25204 | doi=10.1091/mbc.10.4.819}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nangaku M, Sato-Yoshitake R, Okada Y, ''et al.'' |title=KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. |journal=Cell |volume=79 |issue= 7 |pages= 1209-20 |year= 1995 |pmid= 7528108 |doi=  }}
*{{cite journal   |vauthors=Nangaku M, Sato-Yoshitake R, Okada Y, etal |title=KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria |journal=Cell |volume=79 |issue= 7 |pages= 1209–20 |year= 1995 |pmid= 7528108 |doi=10.1016/0092-8674(94)90012-4 }}
*{{cite journal  | author=Gong TL, Burmeister M, Lomax MI |title=The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36. |journal=Mamm. Genome |volume=7 |issue= 10 |pages= 790-1 |year= 1997 |pmid= 8854876 |doi=  }}
*{{cite journal  |vauthors=Gong TL, Burmeister M, Lomax MI |title=The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36 |journal=Mamm. Genome |volume=7 |issue= 10 |pages= 790–1 |year= 1997 |pmid= 8854876 |doi=10.1007/s003359900237 }}
*{{cite journal | author=Saito M, Hayashi Y, Suzuki T, ''et al.'' |title=Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A. |journal=Neurology |volume=49 |issue= 6 |pages= 1630-5 |year= 1998 |pmid= 9409358 |doi=  }}
*{{cite journal   |vauthors=Saito M, Hayashi Y, Suzuki T, etal |title=Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A |journal=Neurology |volume=49 |issue= 6 |pages= 1630–5 |year= 1998 |pmid= 9409358 |doi=  10.1212/wnl.49.6.1630}}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Miyajima N, etal |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 }}
*{{cite journal  | author=Bunn RC, Jensen MA, Reed BC |title=Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. |journal=Mol. Biol. Cell |volume=10 |issue= 4 |pages= 819-32 |year= 1999 |pmid= 10198040 |doi=  }}
*{{cite journal  |vauthors=Bunn RC, Jensen MA, Reed BC |title=Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton |journal=Mol. Biol. Cell |volume=10 |issue= 4 |pages= 819–32 |year= 1999 |pmid= 10198040 |doi= 10.1091/mbc.10.4.819| pmc=25204 }}
*{{cite journal | author=Conforti L, Buckmaster EA, Tarlton A, ''et al.'' |title=The major brain isoform of kif1b lacks the putative mitochondria-binding domain. |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 617-22 |year= 1999 |pmid= 10341097 |doi=  }}
*{{cite journal   |vauthors=Conforti L, Buckmaster EA, Tarlton A, etal |title=The major brain isoform of kif1b lacks the putative mitochondria-binding domain |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 617–22 |year= 1999 |pmid= 10341097 |doi=10.1007/s003359901056 }}
*{{cite journal | author=Nagai M, Ichimiya S, Ozaki T, ''et al.'' |title=Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2. |journal=Int. J. Oncol. |volume=16 |issue= 5 |pages= 907-16 |year= 2000 |pmid= 10762626 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi= }}
*{{cite journal   |vauthors=Yang HW, Chen YZ, Takita J, etal |title=Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2 |journal=Oncogene |volume=20 |issue= 36 |pages= 5075–83 |year= 2001 |pmid= 11526494 |doi= 10.1038/sj.onc.1204456 }}
*{{cite journal | author=Zhao C, Takita J, Tanaka Y, ''et al.'' |title=Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. |journal=Cell |volume=105 |issue= 5 |pages= 587-97 |year= 2001 |pmid= 11389829 |doi=  }}
*{{cite journal   |vauthors=Mok H, Shin H, Kim S, etal |title=Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5253–8 |year= 2002 |pmid= 12097473 }}
*{{cite journal | author=Yang HW, Chen YZ, Takita J, ''et al.'' |title=Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. |journal=Oncogene |volume=20 |issue= 36 |pages= 5075-83 |year= 2001 |pmid= 11526494 |doi= 10.1038/sj.onc.1204456 }}
*{{cite journal   |vauthors=Nakamura N, Miyake Y, Matsushita M, etal |title=KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles |journal=J. Biochem. |volume=132 |issue= 3 |pages= 483–91 |year= 2003 |pmid= 12204119 |doi= 10.1093/oxfordjournals.jbchem.a003246}}
*{{cite journal | author=Mok H, Shin H, Kim S, ''et al.'' |title=Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5253-8 |year= 2002 |pmid= 12097473 |doi= 20026553 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Nakamura N, Miyake Y, Matsushita M, ''et al.'' |title=KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles. |journal=J. Biochem. |volume=132 |issue= 3 |pages= 483-91 |year= 2003 |pmid= 12204119 |doi= }}
*{{cite journal  |vauthors=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638–53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003  | pmc=196011 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Chen YY, Takita J, Chen YZ, etal |title=Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma |journal=Int. J. Oncol. |volume=23 |issue= 3 |pages= 737–44 |year= 2004 |pmid= 12888911 |doi= 10.3892/ijo.23.3.737 }}
*{{cite journal  | author=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB. |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638-53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003 }}
*{{cite journal  |vauthors=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 }}
*{{cite journal  | author=Chen YY, Takita J, Chen YZ, ''et al.'' |title=Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. |journal=Int. J. Oncol. |volume=23 |issue= 3 |pages= 737-44 |year= 2004 |pmid= 12888911 |doi=  }}
*{{cite journal  |vauthors=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654–65 |year= 2004 |pmid= 14697242 |doi=10.1016/j.bbrc.2003.12.001 }}
*{{cite journal | author=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914-8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654-65 |year= 2004 |pmid= 14697242 |doi=  }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
}}
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{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1285/  GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2]
 
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{{Cytoskeletal proteins}}
 
 
{{gene-1-stub}}

Latest revision as of 06:26, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.[1][2][3]


Clinical significance

It is associated with Charcot–Marie–Tooth disease, type 2A1.[3]

Interactions

KIF1B has been shown to interact with GIPC1.[4]

References

  1. ↑ Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (Jun 2001). "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta". Cell. 105 (5): 587–97. doi:10.1016/S0092-8674(01)00363-4. PMID 11389829.
  2. ↑ Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (May 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2". Int J Oncol. 16 (5): 907–16. doi:10.3892/ijo.16.5.907. PMID 10762626.
  3. ↑ 3.0 3.1 "Entrez Gene: KIF1B kinesin family member 1B".
  4. ↑ Bunn, R C; Jensen M A; Reed B C (Apr 1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell. 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040.

Further reading

External links



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