RPS6KA4: Difference between revisions

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Latest revision as of 09:28, 10 September 2017

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.^[1]^[2]^[3]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[3]

Interactions

RPS6KA4 has been shown to interact with MAPK14.^[1]

References

↑ ^1.0 ^1.1 Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677.
↑ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
↑ ^3.0 ^3.1 "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4".

Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–963. doi:10.1126/science.273.5277.959. PMID 8688081.
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–32379. doi:10.1074/jbc.273.49.32377. PMID 9829964.
Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor". J. Biol. Chem. 275 (31): 23549–23558. doi:10.1074/jbc.M002586200. PMID 10806207.
Tomás-Zuber M, Mary JL, Lamour F, et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)". J. Biol. Chem. 276 (8): 5892–5899. doi:10.1074/jbc.M005822200. PMID 11035004.
Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–6333. doi:10.1038/sj.onc.1204007. PMID 11175347.
Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–5178. doi:10.1128/MCB.21.15.5169-5178.2001. PMC 87241. PMID 11438671.
Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts". Mol. Cell. Biol. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
Soloaga A, Thomson S, Wiggin GR, et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. PMC 156769. PMID 12773393.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–547. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
Gesser B, Johansen C, Rasmussen MK, et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect". J. Invest. Dermatol. 127 (9): 2129–2137. doi:10.1038/sj.jid.5700859. PMID 17495961.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid9792677-1] 1.0 ^1.1 Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)". J Biol Chem. 273 (45): 29661–29671. doi:10.1074/jbc.273.45.29661. PMID 9792677.

[pmid9687510-2] Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.

[entrez-3] 3.0 ^3.1 "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Ribosomal protein S6 kinase alpha-4''' is an [[enzyme]] that in humans is encoded by the ''RPS6KA4'' [[gene]].<ref name="pmid9792677">{{cite journal |vauthors=Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W | title = RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK) | journal = J Biol Chem | volume = 273 | issue = 45 | pages = 29661–29671 |date=Dec 1998 | pmid = 9792677 | pmc =  | doi =10.1074/jbc.273.45.29661  }}</ref><ref name="pmid9687510">{{cite journal |vauthors=Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = EMBO J | volume = 17 | issue = 15 | pages = 4426–4441 |date=Sep 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
+== Function ==
+This gene encodes a member of the RSK ([[ribosomal S6 kinase]]) family of [[serine/threonine kinase]]s. This kinase contains 2 non-identical kinase catalytic domains and [[phosphorylates]] various substrates, including [[CREB1]] and [[c-Fos]]. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez"/>
+== Interactions ==
+RPS6KA4 has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]].<ref name="pmid9792677"/>
+== References ==
+{{reflist}}
+== Further reading ==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  |vauthors=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase |journal=Science |volume=273 |issue= 5277 |pages= 959–963 |year= 1996 |pmid= 8688081 |doi=10.1126/science.273.5277.959  }}
+*{{cite journal  |vauthors=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377–32379 |year= 1999 |pmid= 9829964 |doi=10.1074/jbc.273.49.32377  }}
+*{{cite journal  |vauthors=Tomás-Zuber M, Mary JL, Lesslauer W |title=Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23549–23558 |year= 2000 |pmid= 10806207 |doi= 10.1074/jbc.M002586200 }}
+*{{cite journal  | author=Tomás-Zuber M |title=C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB) |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5892–5899 |year= 2001 |pmid= 11035004 |doi= 10.1074/jbc.M005822200  |name-list-format=vanc| author2=Mary JL  | author3=Lamour F  | display-authors=3  | last4=Bur  | first4=D  | last5=Lesslauer  | first5=W }}
+*{{cite journal  | author=Gudi T |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation |journal=Oncogene |volume=19 |issue= 54 |pages= 6324–6333 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007  |name-list-format=vanc| author2=Casteel DE  | author3=Vinson C  | display-authors=3  | last4=Boss  | first4=Gerry R  | last5=Pilz  | first5=Renate B }}
+*{{cite journal  | author=Prymakowska-Bosak M |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169–5178 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001  | pmc=87241  |name-list-format=vanc| author2=Misteli T  | author3=Herrera JE  | display-authors=3  | last4=Shirakawa  | first4=H.  | last5=Birger  | first5=Y.  | last6=Garfield  | first6=S.  | last7=Bustin  | first7=M. }}
+*{{cite journal  | author=Wiggin GR |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871–2881 |year= 2002 |pmid= 11909979 |doi=10.1128/MCB.22.8.2871-2881.2002  | pmc=133730  |name-list-format=vanc| author2=Soloaga A  | author3=Foster JM  | display-authors=3  | last4=Murray-Tait  | first4=V.  | last5=Cohen  | first5=P.  | last6=Arthur  | first6=J. S. C.  }}
+*{{cite journal  | author=Soloaga A |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788–2797 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273  | pmc=156769  |name-list-format=vanc| author2=Thomson S  | author3=Wiggin GR  | display-authors=3  | last4=Rampersaud  | first4=N  | last5=Dyson  | first5=MH  | last6=Hazzalin  | first6=CA  | last7=Mahadevan  | first7=LC  | last8=Arthur  | first8=JS }}
+*{{cite journal  | author=Wissing J |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–547 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200  |name-list-format=vanc| author2=Jänsch L  | author3=Nimtz M  | display-authors=3  | last4=Dieterich  | first4=G.  | last5=Hornberger  | first5=R.  | last6=Keri  | first6=G.  | last7=Wehland  | first7=J.  | last8=Daub  | first8=H. }}
+*{{cite journal  | author=Gesser B |title=Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2129–2137 |year= 2007 |pmid= 17495961 |doi= 10.1038/sj.jid.5700859  |name-list-format=vanc| author2=Johansen C  | author3=Rasmussen MK  | display-authors=3  | last4=Funding  | first4=Anne T  | last5=Otkjaer  | first5=Kristian  | last6=Kjellerup  | first6=Rasmus B  | last7=Kragballe  | first7=Knud  | last8=Iversen  | first8=Lars }}
+}}
+{{refend}}
+{{Serine/threonine-specific protein kinases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
 {{PBB_Controls
@@ Line 4: / Line 39: @@
 | require_manual_inspection = no
 | update_protein_box = yes
-| update_summary = yes
+| update_summary = no
-| update_citations = yes
+| update_citations = no
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Category:EC 2.7.11]]
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 4
- | HGNCid = 10433
- | Symbol = RPS6KA4
- | AltSymbols =; MSK2; RSK-B
- | OMIM = 603606
- | ECnumber =
- | Homologene = 69288
- | MGIid = 1930076
- | GeneAtlas_image1 = PBB_GE_RPS6KA4_204632_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004711 |text = ribosomal protein S6 kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0048273 |text = mitogen-activated protein kinase p38 binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8986
-    | Hs_Ensembl = ENSG00000162302
-    | Hs_RefseqProtein = NP_001006945
-    | Hs_RefseqmRNA = NM_001006944
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 63883201
-    | Hs_GenLoc_end = 63896263
-    | Hs_Uniprot = O75676
-    | Mm_EntrezGene = 56613
-    | Mm_Ensembl = ENSMUSG00000024952
-    | Mm_RefseqmRNA = NM_019924
-    | Mm_RefseqProtein = NP_064308
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 19
-    | Mm_GenLoc_start = 6896129
-    | Mm_GenLoc_end = 6907671
-    | Mm_Uniprot = Q3U3M8
-  }}
-}}
-'''Ribosomal protein S6 kinase, 90kDa, polypeptide 4''', also known as '''RPS6KA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = }}</ref>
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959-63 |year= 1996 |pmid= 8688081 |doi=  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
-*{{cite journal  | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426-41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426 }}
-*{{cite journal  | author=Pierrat B, Correia JS, Mary JL, ''et al.'' |title=RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29661-71 |year= 1998 |pmid= 9792677 |doi=  }}
-*{{cite journal  | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377-9 |year= 1999 |pmid= 9829964 |doi=  }}
-*{{cite journal  | author=Zhu S, Gerhard DS |title=A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 674-80 |year= 1999 |pmid= 9921902 |doi=  }}
-*{{cite journal  | author=Tomás-Zuber M, Mary JL, Lesslauer W |title=Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23549-58 |year= 2000 |pmid= 10806207 |doi= 10.1074/jbc.M002586200 }}
-*{{cite journal  | author=Tomás-Zuber M, Mary JL, Lamour F, ''et al.'' |title=C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5892-9 |year= 2001 |pmid= 11035004 |doi= 10.1074/jbc.M005822200 }}
-*{{cite journal  | author=Gudi T, Casteel DE, Vinson C, ''et al.'' |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. |journal=Oncogene |volume=19 |issue= 54 |pages= 6324-33 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007 }}
-*{{cite journal  | author=Prymakowska-Bosak M, Misteli T, Herrera JE, ''et al.'' |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169-78 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001 }}
-*{{cite journal  | author=Wiggin GR, Soloaga A, Foster JM, ''et al.'' |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871-81 |year= 2002 |pmid= 11909979 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Soloaga A, Thomson S, Wiggin GR, ''et al.'' |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788-97 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273 }}
-*{{cite journal  | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
-*{{cite journal  | author=Gesser B, Johansen C, Rasmussen MK, ''et al.'' |title=Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2129-37 |year= 2007 |pmid= 17495961 |doi= 10.1038/sj.jid.5700859 }}
-}}
-{{refend}}
-{{protein-stub}}
+{{gene-11-stub}}
-{{WikiDoc Sources}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

RPS6KA4: Difference between revisions

Latest revision as of 09:28, 10 September 2017

Contents

Function

Interactions

References

Further reading

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