SLCO1A2: Difference between revisions

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{{Infobox_gene}}
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'''Solute carrier organic anion transporter family member 1A2''' is a [[protein]] that in humans is encoded by the ''SLCO1A2'' [[gene]].<ref name="pmid9007731">{{cite journal | vauthors = Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G | title = Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization | journal = J Hepatol | volume = 25 | issue = 6 | pages = 985–7 |date=Apr 1997 | pmid = 9007731 | pmc =  | doi =10.1016/S0168-8278(96)80307-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6579| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Solute carrier organic anion transporter family, member 1A2
| HGNCid = 10956
| Symbol = SLCO1A2
| AltSymbols =; OATP; OATP-A; OATP1A2; SLC21A3
| OMIM = 602883
| ECnumber = 
| Homologene = 56603
| MGIid = 1351896
| GeneAtlas_image1 = PBB_GE_SLCO1A2_207308_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLCO1A2_211480_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLCO1A2_211481_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0008514 |text = organic anion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0015711 |text = organic anion transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6579
    | Hs_Ensembl = ENSG00000084453
    | Hs_RefseqProtein = NP_005066
    | Hs_RefseqmRNA = NM_005075
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 21313094
    | Hs_GenLoc_end = 21439638
    | Hs_Uniprot = P46721
    | Mm_EntrezGene = 28250
    | Mm_Ensembl = ENSMUSG00000030237
    | Mm_RefseqmRNA = NM_030687
    | Mm_RefseqProtein = NP_109612
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 141767844
    | Mm_GenLoc_end = 141807926
    | Mm_Uniprot = Q8C7H7
  }}
}}
'''Solute carrier organic anion transporter family, member 1A2''', also known as '''SLCO1A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6579| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6579| accessdate = }}</ref>
| summary_text = This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Meier PJ, Eckhardt U, Schroeder A, ''et al.'' |title=Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. |journal=Hepatology |volume=26 |issue= 6 |pages= 1667-77 |year= 1998 |pmid= 9398014 |doi= 10.1002/hep.510260641 }}
*{{cite journal   |vauthors=Meier PJ, Eckhardt U, Schroeder A, etal |title=Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver |journal=Hepatology |volume=26 |issue= 6 |pages= 1667–77 |year= 1998 |pmid= 9398014 |doi= 10.1002/hep.510260641 }}
*{{cite journal | author=Kullak-Ublick GA, Hagenbuch B, Stieger B, ''et al.'' |title=Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. |journal=Gastroenterology |volume=109 |issue= 4 |pages= 1274-82 |year= 1995 |pmid= 7557095 |doi= }}
*{{cite journal   |vauthors=Kullak-Ublick GA, Hagenbuch B, Stieger B, etal |title=Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver |journal=Gastroenterology |volume=109 |issue= 4 |pages= 1274–82 |year= 1995 |pmid= 7557095 |doi=10.1016/0016-5085(95)90588-X }}
*{{cite journal  | author=Kullak-Ublick GA, Beuers U, Meier PJ, ''et al.'' |title=Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization. |journal=J. Hepatol. |volume=25 |issue= 6 |pages= 985-7 |year= 1997 |pmid= 9007731 |doi= }}
*{{cite journal   |vauthors=Kullak-Ublick GA, Beuers U, Fahney C, etal |title=Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene |journal=Hepatology |volume=26 |issue= 4 |pages= 991–7 |year= 1997 |pmid= 9328325 |doi= 10.1002/hep.510260429 }}
*{{cite journal | author=Kullak-Ublick GA, Beuers U, Fahney C, ''et al.'' |title=Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. |journal=Hepatology |volume=26 |issue= 4 |pages= 991-7 |year= 1997 |pmid= 9328325 |doi= 10.1002/hep.510260429 }}
*{{cite journal   |vauthors=Kullak-Ublick GA, Fisch T, Oswald M, etal |title=Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain |journal=FEBS Lett. |volume=424 |issue= 3 |pages= 173–6 |year= 1998 |pmid= 9539145 |doi=10.1016/S0014-5793(98)00168-9 }}
*{{cite journal | author=Kullak-Ublick GA, Fisch T, Oswald M, ''et al.'' |title=Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. |journal=FEBS Lett. |volume=424 |issue= 3 |pages= 173-6 |year= 1998 |pmid= 9539145 |doi=  }}
*{{cite journal  | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 }}
*{{cite journal  | author=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161-8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 }}
*{{cite journal   |vauthors=Tamai I, Nezu J, Uchino H, etal |title=Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 251–60 |year= 2000 |pmid= 10873595 |doi= 10.1006/bbrc.2000.2922 }}
*{{cite journal | author=Tamai I, Nezu J, Uchino H, ''et al.'' |title=Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 251-60 |year= 2000 |pmid= 10873595 |doi= 10.1006/bbrc.2000.2922 }}
*{{cite journal  | author=Speek M |title=Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1973–85 |year= 2001 |pmid= 11238933 |doi= 10.1128/MCB.21.6.1973-1985.2001 | pmc=86790 }}
*{{cite journal  | author=Speek M |title=Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1973-85 |year= 2001 |pmid= 11238933 |doi= 10.1128/MCB.21.6.1973-1985.2001 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lee W, Glaeser H, Smith LH, etal |title=Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9610–7 |year= 2005 |pmid= 15632119 |doi= 10.1074/jbc.M411092200 }}
*{{cite journal | author=Lee W, Glaeser H, Smith LH, ''et al.'' |title=Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9610-7 |year= 2005 |pmid= 15632119 |doi= 10.1074/jbc.M411092200 }}
*{{cite journal  | vauthors=Su Y, Zhang X, Sinko PJ |title=Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells |journal=Mol. Pharm. |volume=1 |issue= 1 |pages= 49–56 |year= 2005 |pmid= 15832500 |doi=10.1021/mp0340136 }}
*{{cite journal  | author=Su Y, Zhang X, Sinko PJ |title=Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. |journal=Mol. Pharm. |volume=1 |issue= 1 |pages= 49-56 |year= 2005 |pmid= 15832500 |doi=  }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:37, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.[1][2]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[2]

See also

References

  1. ↑ Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
  2. ↑ 2.0 2.1 "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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