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{{Infobox_gene}}
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'''Keratin, type II cuticular Hb1''' is a [[protein]] that in humans is encoded by the ''KRT81'' [[gene]].<ref name="pmid7556444">{{cite journal |vauthors=Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J | title = Sequence data and chromosomal localization of human type I and type II hair keratin genes | journal = Exp Cell Res | volume = 220 | issue = 2 | pages = 357–62 |date=Nov 1995 | pmid = 7556444 | pmc =  | doi = 10.1006/excr.1995.1326 }}</ref><ref name="pmid16831889">{{cite journal |vauthors=Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW | title = New consensus nomenclature for mammalian keratins | journal = J Cell Biol | volume = 174 | issue = 2 | pages = 169–74 |date=Jul 2006 | pmid = 16831889 | pmc = 2064177 | doi = 10.1083/jcb.200603161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KRT81 keratin 81| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3887| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 81
| HGNCid = 6458
| Symbol = KRT81
| AltSymbols =; HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
| OMIM = 602153
| ECnumber =
| Homologene = 55645
| MGIid =
  | GeneAtlas_image1 = PBB_GE_KRT81_213711_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}  
| Component = {{GNF_GO|id=GO:0005882 |text = intermediate filament}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3887
    | Hs_Ensembl = ENSG00000205426
    | Hs_RefseqProtein = NP_002272
    | Hs_RefseqmRNA = NM_002281
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 50965966
    | Hs_GenLoc_end = 50971566
    | Hs_Uniprot = Q14533
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Keratin 81''', also known as '''KRT81''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KRT81 keratin 81| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3887| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.<ref name="entrez">{{cite web | title = Entrez Gene: KRT81 keratin 81| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3887| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.<ref name="entrez">{{cite web | title = Entrez Gene: KRT81 keratin 81| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3887| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Coulombe PA, Omary MB |title='Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 1 |pages= 110-22 |year= 2002 |pmid= 11792552 |doi=  }}
*{{cite journal  |vauthors=Coulombe PA, Omary MB |title='Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 1 |pages= 110–22 |year= 2002 |pmid= 11792552 |doi=10.1016/S0955-0674(01)00301-5 }}
*{{cite journal  | author=Langbein L, Schweizer J |title=Keratins of the human hair follicle. |journal=Int. Rev. Cytol. |volume=243 |issue=  |pages= 1-78 |year= 2005 |pmid= 15797458 |doi= 10.1016/S0074-7696(05)43001-6 }}
*{{cite journal  |vauthors=Langbein L, Schweizer J |title=Keratins of the human hair follicle. |journal=Int. Rev. Cytol. |volume=243 |issue=  |pages= 1–78 |year= 2005 |pmid= 15797458 |doi= 10.1016/S0074-7696(05)43001-6 }}
*{{cite journal | author=Tomasetto C, Régnier C, Moog-Lutz C, ''et al.'' |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367-76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163 }}
*{{cite journal   |vauthors=Tomasetto C, Régnier C, Moog-Lutz C, etal |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367–76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163 }}
*{{cite journal  | author=Bowden PE, Hainey S, Parker G, Hodgins MB |title=Sequence and expression of human hair keratin genes. |journal=J. Dermatol. Sci. |volume=7 Suppl |issue=  |pages= S152-63 |year= 1995 |pmid= 7528047 |doi=  }}
*{{cite journal  |vauthors=Bowden PE, Hainey S, Parker G, Hodgins MB |title=Sequence and expression of human hair keratin genes. |journal=J. Dermatol. Sci. |volume=7 Suppl |issue=  |pages= S152–63 |year= 1995 |pmid= 7528047 |doi= 10.1016/0923-1811(94)90046-9  }}
*{{cite journal  | author=Rogers MA, Nischt R, Korge B, ''et al.'' |title=Sequence data and chromosomal localization of human type I and type II hair keratin genes. |journal=Exp. Cell Res. |volume=220 |issue= 2 |pages= 357-62 |year= 1995 |pmid= 7556444 |doi= 10.1006/excr.1995.1326 }}
*{{cite journal   |vauthors=Winter H, Rogers MA, Gebhardt M, etal |title=A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 165–9 |year= 1998 |pmid= 9402962 |doi=10.1007/s004390050607 }}
*{{cite journal | author=Winter H, Rogers MA, Gebhardt M, ''et al.'' |title=A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. |journal=Hum. Genet. |volume=101 |issue= 2 |pages= 165-9 |year= 1998 |pmid= 9402962 |doi=  }}
*{{cite journal   |vauthors=Bowden PE, Hainey SD, Parker G, etal |title=Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 158–64 |year= 1998 |pmid= 9457912 |doi= 10.1046/j.1523-1747.1998.00097.x }}
*{{cite journal | author=Bowden PE, Hainey SD, Parker G, ''et al.'' |title=Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 158-64 |year= 1998 |pmid= 9457912 |doi= 10.1046/j.1523-1747.1998.00097.x }}
*{{cite journal   |vauthors=Winter H, Labrèze C, Chapalain V, etal |title=A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 169–72 |year= 1998 |pmid= 9665406 |doi= 10.1046/j.1523-1747.1998.00234.x }}
*{{cite journal | author=Winter H, Labrèze C, Chapalain V, ''et al.'' |title=A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 169-72 |year= 1998 |pmid= 9665406 |doi= 10.1046/j.1523-1747.1998.00234.x }}
*{{cite journal   |vauthors=Rogers MA, Winter H, Langbein L, etal |title=Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. |journal=J. Invest. Dermatol. |volume=114 |issue= 3 |pages= 464–72 |year= 2000 |pmid= 10692104 |doi= 10.1046/j.1523-1747.2000.00910.x }}
*{{cite journal | author=Rogers MA, Winter H, Langbein L, ''et al.'' |title=Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. |journal=J. Invest. Dermatol. |volume=114 |issue= 3 |pages= 464-72 |year= 2000 |pmid= 10692104 |doi= 10.1046/j.1523-1747.2000.00910.x }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nishikawa J, Kiss C, Imai S, etal |title=Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV). |journal=Int. J. Cancer |volume=107 |issue= 4 |pages= 597–602 |year= 2003 |pmid= 14520698 |doi= 10.1002/ijc.11289 }}
*{{cite journal | author=Nishikawa J, Kiss C, Imai S, ''et al.'' |title=Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV). |journal=Int. J. Cancer |volume=107 |issue= 4 |pages= 597-602 |year= 2003 |pmid= 14520698 |doi= 10.1002/ijc.11289 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Schweizer J, Bowden PE, Coulombe PA, ''et al.'' |title=New consensus nomenclature for mammalian keratins. |journal=J. Cell Biol. |volume=174 |issue= 2 |pages= 169-74 |year= 2006 |pmid= 16831889 |doi= 10.1083/jcb.200603161 }}
}}
}}
{{refend}}
{{refend}}


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{{Cytoskeletal proteins}}
 
 
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Latest revision as of 06:38, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[3]

References

  1. ↑ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res. 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
  2. ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  3. ↑ 3.0 3.1 "Entrez Gene: KRT81 keratin 81".

Further reading



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