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{{Infobox_gene}}
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'''Serine/threonine protein kinase NLK''' is an [[enzyme]] that in humans is encoded by the ''NLK'' [[gene]].<ref name="pmid9448268">{{cite journal |vauthors=Brott BK, Pinsky BA, Erikson RL | title = Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 3 | pages = 963–8 |date=Mar 1998 | pmid = 9448268 | pmc = 18639 | doi =10.1073/pnas.95.3.963 }}</ref><ref name="pmid10863097">{{cite journal |vauthors=Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W | title = Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts | journal = Gene | volume = 251 | issue = 1 | pages = 63–71 |date=Jul 2000 | pmid = 10863097 | pmc = | doi =10.1016/S0378-1119(00)00188-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLK nemo-like kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51701| accessdate = }}</ref> Its name is an abbreviation for ''Nemo-Like Kinase'', Nemo (nmo) being the ''[[Drosophila melanogaster|Drosophila]]'' [[ortholog]] of the mammalian NLK gene.<ref name="pmid23000342">{{cite journal |vauthors=Ishitani T, Ishitani S |title=Nemo-like kinase, a multifaceted cell signaling regulator |journal=Cell. Signal. |volume=25 |issue=1 |pages=190–7 |date=January 2013 |pmid=23000342 |doi=10.1016/j.cellsig.2012.09.017 |url=}}</ref> This enzyme is a member of the [[Mitogen-activated protein kinase]] (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual [[phosphorylation]] motifs of typical MAPKs, and is not phosphorylated by any known [[Mitogen-activated protein kinase kinase|MAP2 kinases]]). Its activation mechanism and downstream targets are still not well characterized.<ref name="pmid17161475">{{cite journal |vauthors=Coulombe P, Meloche S |title=Atypical mitogen-activated protein kinases: structure, regulation and functions |journal=Biochim. Biophys. Acta |volume=1773 |issue=8 |pages=1376–87 |date=August 2007 |pmid=17161475 |doi=10.1016/j.bbamcr.2006.11.001 |url=}}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nemo-like kinase
| HGNCid = 29858
| Symbol = NLK
| AltSymbols =; DKFZp761G1211; FLJ21033
| OMIM = 609476
| ECnumber =
| Homologene = 88836
| MGIid =   
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004707 |text = MAP kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51701
    | Hs_Ensembl = ENSG00000087095
    | Hs_RefseqProtein = NP_057315
    | Hs_RefseqmRNA = NM_016231
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 23393309
    | Hs_GenLoc_end = 23547529
    | Hs_Uniprot = Q9UBE8
    | Mm_EntrezGene =
    | Mm_Ensembl =
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start =
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nemo-like kinase''', also known as '''NLK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NLK nemo-like kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51701| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Brott BK, Pinsky BA, Erikson RL |title=Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 3 |pages= 963-8 |year= 1998 |pmid= 9448268 |doi=  }}
*{{cite journal   |vauthors=Volorio S, Simon G, Repetto M, etal |title=Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein. |journal=DNA Seq. |volume=9 |issue= 5-6 |pages= 307–15 |year= 1999 |pmid= 10524757 |doi=10.3109/10425179809008469 }}
*{{cite journal  | author=Volorio S, Simon G, Repetto M, ''et al.'' |title=Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein. |journal=DNA Seq. |volume=9 |issue= 5-6 |pages= 307-15 |year= 1999 |pmid= 10524757 |doi=  }}
*{{cite journal  |vauthors=Kortenjann M, Wehrle C, Nehls MC, Boehm T |title=Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes. |journal=Gene |volume=278 |issue= 1-2 |pages= 161–5 |year= 2002 |pmid= 11707333 |doi=10.1016/S0378-1119(01)00710-7 }}
*{{cite journal | author=Kehrer-Sawatzki H, Moschgath E, Maier C, ''et al.'' |title=Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. |journal=Gene |volume=251 |issue= 1 |pages= 63-71 |year= 2000 |pmid= 10863097 |doi=  }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Wyatt MK, etal |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. |journal=Mol. Vis. |volume=8 |issue= |pages= 196–204 |year= 2002 |pmid= 12107411 |doi=  }}
*{{cite journal | author=Kortenjann M, Wehrle C, Nehls MC, Boehm T |title=Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes. |journal=Gene |volume=278 |issue= 1-2 |pages= 161-5 |year= 2002 |pmid= 11707333 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. |journal=Mol. Vis. |volume=8 |issue= |pages= 196-204 |year= 2002 |pmid= 12107411 |doi= }}
*{{cite journal   |vauthors=Ishitani T, Kishida S, Hyodo-Miura J, etal |title=The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 131–9 |year= 2003 |pmid= 12482967 |doi=10.1128/MCB.23.1.131-139.2003  | pmc=140665  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Ishitani T, Ninomiya-Tsuji J, Matsumoto K |title=Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 4 |pages= 1379–89 |year= 2003 |pmid= 12556497 |doi=10.1128/MCB.23.4.1379-1389.2003  | pmc=141159  }}
*{{cite journal | author=Ishitani T, Kishida S, Hyodo-Miura J, ''et al.'' |title=The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 131-9 |year= 2003 |pmid= 12482967 |doi=  }}
*{{cite journal   |vauthors=Yasuda J, Tsuchiya A, Yamada T, etal |title=Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 227–33 |year= 2003 |pmid= 12901858 |doi=10.1016/S0006-291X(03)01343-3 }}
*{{cite journal | author=Ishitani T, Ninomiya-Tsuji J, Matsumoto K |title=Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 4 |pages= 1379-89 |year= 2003 |pmid= 12556497 |doi= }}
*{{cite journal   |vauthors=Yasuda J, Yokoo H, Yamada T, etal |title=Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. |journal=Cancer Sci. |volume=95 |issue= 1 |pages= 52–7 |year= 2004 |pmid= 14720327 |doi=10.1111/j.1349-7006.2004.tb03170.x  }}
*{{cite journal | author=Yasuda J, Tsuchiya A, Yamada T, ''et al.'' |title=Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 227-33 |year= 2003 |pmid= 12901858 |doi=  }}
*{{cite journal  |vauthors=Smit L, Baas A, Kuipers J, etal |title=Wnt activates the Tak1/Nemo-like kinase pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17232–40 |year= 2004 |pmid= 14960582 |doi= 10.1074/jbc.M307801200 }}
*{{cite journal | author=Yasuda J, Yokoo H, Yamada T, ''et al.'' |title=Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. |journal=Cancer Sci. |volume=95 |issue= 1 |pages= 52-7 |year= 2004 |pmid= 14720327 |doi= }}
*{{cite journal   |vauthors=Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, etal |title=Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. |journal=Genes Dev. |volume=18 |issue= 7 |pages= 816–29 |year= 2004 |pmid= 15082531 |doi= 10.1101/gad.1170604 | pmc=387421 }}
*{{cite journal | author=Smit L, Baas A, Kuipers J, ''et al.'' |title=Wnt activates the Tak1/Nemo-like kinase pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17232-40 |year= 2004 |pmid= 14960582 |doi= 10.1074/jbc.M307801200 }}
*{{cite journal   |vauthors=Kanei-Ishii C, Nomura T, Tanikawa J, etal |title=Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44582–9 |year= 2004 |pmid= 15308626 |doi= 10.1074/jbc.M407831200 }}
*{{cite journal | author=Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, ''et al.'' |title=Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. |journal=Genes Dev. |volume=18 |issue= 7 |pages= 816-29 |year= 2004 |pmid= 15082531 |doi= 10.1101/gad.1170604 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Kanei-Ishii C, Nomura T, Tanikawa J, ''et al.'' |title=Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44582-9 |year= 2004 |pmid= 15308626 |doi= 10.1074/jbc.M407831200 }}
*{{cite journal   |vauthors=Kojima H, Sasaki T, Ishitani T, etal |title=STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 12 |pages= 4524–9 |year= 2005 |pmid= 15764709 |doi= 10.1073/pnas.0500679102  | pmc=555521 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal  | author=Kojima H, Sasaki T, Ishitani T, ''et al.'' |title=STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 12 |pages= 4524-9 |year= 2005 |pmid= 15764709 |doi= 10.1073/pnas.0500679102 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Gohda J, Irisawa M, Tanaka Y, etal |title=HTLV-1 Tax-induced NFkappaB activation is independent of Lys-63-linked-type polyubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 225–30 |year= 2007 |pmid= 17418100 |doi= 10.1016/j.bbrc.2007.03.125 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gohda J, Irisawa M, Tanaka Y, ''et al.'' |title=HTLV-1 Tax-induced NFkappaB activation is independent of Lys-63-linked-type polyubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 225-30 |year= 2007 |pmid= 17418100 |doi= 10.1016/j.bbrc.2007.03.125 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{MAP kinase activation}}
{{WikiDoc Sources}}
{{Serine/threonine-specific protein kinases}}
 
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[[Category:Protein kinases]]
 
 
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Latest revision as of 13:04, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene.[1][2][3] Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophila ortholog of the mammalian NLK gene.[4] This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it does not even have a numbered MAPK code). It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases (e.g. it does not have the dual phosphorylation motifs of typical MAPKs, and is not phosphorylated by any known MAP2 kinases). Its activation mechanism and downstream targets are still not well characterized.[5]


References

  1. ↑ Brott BK, Pinsky BA, Erikson RL (Mar 1998). "Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus". Proc Natl Acad Sci U S A. 95 (3): 963–8. doi:10.1073/pnas.95.3.963. PMC 18639. PMID 9448268.
  2. ↑ Kehrer-Sawatzki H, Moschgath E, Maier C, Legius E, Elgar G, Krone W (Jul 2000). "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts". Gene. 251 (1): 63–71. doi:10.1016/S0378-1119(00)00188-8. PMID 10863097.
  3. ↑ "Entrez Gene: NLK nemo-like kinase".
  4. ↑ Ishitani T, Ishitani S (January 2013). "Nemo-like kinase, a multifaceted cell signaling regulator". Cell. Signal. 25 (1): 190–7. doi:10.1016/j.cellsig.2012.09.017. PMID 23000342.
  5. ↑ Coulombe P, Meloche S (August 2007). "Atypical mitogen-activated protein kinases: structure, regulation and functions". Biochim. Biophys. Acta. 1773 (8): 1376–87. doi:10.1016/j.bbamcr.2006.11.001. PMID 17161475.

Further reading


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